Literature DB >> 28274039

Evaluation of Gengigel® Application in the Management of Furcation with Coronally Advanced Flap through Surgical Re-Entry-A Split Mouth Clinical Study.

Sugandha Gupta1, Suresh D Kediege2, Akanksha Gupta3, Kanu Jain4.   

Abstract

INTRODUCTION: One of the challenging and unique periodontal problem of Grade II furcation defect has been managed through different treatment modalities in the past. A successful approach is based on complete closure of the defect. Different regenerative approaches have been tried. AIM: This study was carried out with an aim to evaluate the role of Gengigel® (0.8% hyaluronic acid) as a potential material for regeneration of lost attachment apparatus.
MATERIALS AND METHODS: A total of 20 sites with Grade II furcation defects from 10 patients were selected using random sampling technique. These were divided into Group A (placement of hyaluronic acid) and Group B (without placement of hyaluronic acid) according to treatment modality. Furcation defect assessment was done in vertical and horizontal depth preoperatively and postoperatively at six months through surgical re-entry. Recorded data was subjected to the statistical analysis unpaired and paired t-tests for intergroup and intragroup comparisons respectively.
RESULTS: Mean plaque index, gingival index and bleeding index score showed statistically highly significant and significant results respectively, for both the groups at baseline and six months. Mean difference in probing pocket depth and Relative Attachment Level (RAL) were statistically highly significant, whereas, mean difference of gingival position margin was non significant for both the groups, at baseline and six months. Mean difference in horizontal component at baseline and six months was statistically highly significant for both the groups. Mean difference in vertical component at baseline and six months was statistically significant for both the groups. On comparison, the mean difference in vertical and horizontal component of Group A and Group B at six months was statistically not significant.
CONCLUSION: Both Gengigel® with coronally positioned flap and coronally positioned flap alone are effective in the treatment of Grade II furcation defects. The combination of Gengigel® with coronally positioned flap leads to better results in hard tissue measurement as compared to coronally positioned flap alone.

Entities:  

Keywords:  Hyaluronic acid; Periodontitis; Regeneration

Year:  2017        PMID: 28274039      PMCID: PMC5324490          DOI: 10.7860/JCDR/2017/21938.9169

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  34 in total

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5.  An evaluation of bovine derived xenograft with and without a bioabsorbable collagen membrane in the treatment of mandibular Class II furcation defects.

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Journal:  Aust Dent J       Date:  2009-09       Impact factor: 2.291

6.  The role of viscosupplementation with hylan G-F 20 (Synvisc) in the treatment of osteoarthritis of the knee: a Canadian multicenter trial comparing hylan G-F 20 alone, hylan G-F 20 with non-steroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone.

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Journal:  Osteoarthritis Cartilage       Date:  1995-12       Impact factor: 6.576

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Journal:  Curr Opin Periodontol       Date:  1997

8.  Effect of a new cohesive ophthalmic viscosurgical device on corneal protection and intraocular pressure in small-incision cataract surgery.

Authors:  Thomas Neumayer; Ana Prinz; Oliver Findl
Journal:  J Cataract Refract Surg       Date:  2008-08       Impact factor: 3.351

9.  Surgical re-entry evaluation of regenerative efficacy of bioactive Gengigel(®) and platelet-rich fibrin in the treatment of grade II furcation: A novel approach.

Authors:  Gurkirat Kaur Sandhu; Paramjit Kaur Khinda; Amarjit Singh Gill; Harveen Singh Kalra
Journal:  Contemp Clin Dent       Date:  2015 Oct-Dec

10.  Esterified hyaluronic acid and autologous bone in the surgical correction of the infra-bone defects.

Authors:  Andrea Ballini; Stefania Cantore; Saverio Capodiferro; Felice Roberto Grassi
Journal:  Int J Med Sci       Date:  2009-02-26       Impact factor: 3.738

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  1 in total

1.  Lipopolysaccharide-Preconditioned Dental Follicle Stem Cells Derived Small Extracellular Vesicles Treating Periodontitis via Reactive Oxygen Species/Mitogen-Activated Protein Kinase Signaling-Mediated Antioxidant Effect.

Authors:  Yanli Huang; Qian Liu; Li Liu; Fangjun Huo; Shujuan Guo; Weidong Tian
Journal:  Int J Nanomedicine       Date:  2022-02-22
  1 in total

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