Kuotho T Nyuwi1, Ch Gyan Singh2, Sridartha Khumukcham3, Raju Rangaswamy1, Yibenthung S Ezung1, Sowdin Reddy Chittvolu1, A Barindra Sharma4, H Manihar Singh5. 1. Junior Resident, Department of General Surgery, Regional Institute of Medical Sciences , Imphal West, Manipur, India . 2. Assistant professor, Department of General Surgery, Regional Institute of Medical Sciences , Imphal West, Manipur, India . 3. Senior Resident, Department of General Surgery, Regional Institute of Medical Sciences , Imphal West, Manipur, India . 4. Professor, Department of Department of Immunohaematology and Blood Transfusion, Regional Institute of Medical Sciences , Imphal West, Manipur, India . 5. Professor, Department of General Surgery, Regional Institute of Medical Sciences , Imphal West, Manipur, India .
Abstract
INTRODUCTION: Acute appendicitis is the most common indication for emergent surgery and affects a wide range of patients at any age group. However, inspite of the presence of various imaging modalities, biochemical markers, and scoring systems the negative appendectomy rate remain high. Serum fibrinogen, an acute inflammatory mediator is usually raised in any acute inflammatory condition and the same is expected to rise in acute appendicitis, which may be used as a new inflammatory marker in the diagnosis and more importantly in decision making of management of acute appendicitis. AIM: To determine the relationship between the rise in the level of serum fibrinogen and acute appendicitis and its role in reducing the negative appendectomy rate. MATERIALS AND METHODS: A total of 82 patients with clinical signs and symptoms of acute appendicitis who underwent emergency appendectomy were included in the study, the serum fibrinogen level were measured just before the operation and the sensitivity and the specificity was calculated. The final diagnosis was based on the histopathological examination. RESULTS: In our study, the Mean±SD of serum fibrinogen in mg/dl in those patient proved to be having acute appendicitis by histopathology was 436.6±40.6 while those with normal appendix was 391.91±66.54. The area under the curve was 0.697 i.e., it has an accuracy of around 70% and this is statistically significant (p=0.018). On further sub-analysis when the cut off level of fibrinogen level was reduced to 397, it resulted in a sensitivity of 82% and specificity of 60% and if the level was further reduced to 375 it increased the sensitivity to 88% with a specificity of 55%. CONCLUSION: In the diagnosis of acute appendicitis, use of fibrinogen blood level may be a new diagnostic acute-phase reactant with possible role in reducing negative appendectomy rate.
INTRODUCTION:Acute appendicitis is the most common indication for emergent surgery and affects a wide range of patients at any age group. However, inspite of the presence of various imaging modalities, biochemical markers, and scoring systems the negative appendectomy rate remain high. Serum fibrinogen, an acute inflammatory mediator is usually raised in any acute inflammatory condition and the same is expected to rise in acute appendicitis, which may be used as a new inflammatory marker in the diagnosis and more importantly in decision making of management of acute appendicitis. AIM: To determine the relationship between the rise in the level of serum fibrinogen and acute appendicitis and its role in reducing the negative appendectomy rate. MATERIALS AND METHODS: A total of 82 patients with clinical signs and symptoms of acute appendicitis who underwent emergency appendectomy were included in the study, the serum fibrinogen level were measured just before the operation and the sensitivity and the specificity was calculated. The final diagnosis was based on the histopathological examination. RESULTS: In our study, the Mean±SD of serum fibrinogen in mg/dl in those patient proved to be having acute appendicitis by histopathology was 436.6±40.6 while those with normal appendix was 391.91±66.54. The area under the curve was 0.697 i.e., it has an accuracy of around 70% and this is statistically significant (p=0.018). On further sub-analysis when the cut off level of fibrinogen level was reduced to 397, it resulted in a sensitivity of 82% and specificity of 60% and if the level was further reduced to 375 it increased the sensitivity to 88% with a specificity of 55%. CONCLUSION: In the diagnosis of acute appendicitis, use of fibrinogen blood level may be a new diagnostic acute-phase reactant with possible role in reducing negative appendectomy rate.
Authors: Jasper J Atema; Sarah L Gans; Ludo F Beenen; Boudewijn R Toorenvliet; Helena Laurell; Jaap Stoker; Marja A Boermeester Journal: Acad Emerg Med Date: 2015-08-20 Impact factor: 3.451
Authors: F A Alvarez-Alvarez; V M Maciel-Gutierrez; A D Rocha-Muñoz; J H Lujan; C F Ploneda-Valencia Journal: Int J Surg Date: 2015-11-28 Impact factor: 6.071
Authors: Ąžuolas Algimantas Kaminskas; Raminta Lukšaitė-Lukštė; Eugenijus Jasiūnas; Artūras Samuilis; Vytautas Augustinavičius; Marius Kryžauskas; Kęstutis Strupas; Tomas Poškus Journal: Medicina (Kaunas) Date: 2021-12-20 Impact factor: 2.430