Literature DB >> 2827385

Oligopeptides inhibit the ribonucleotide reductase of herpes simplex virus by causing subunit separation.

W McClements1, G Yamanaka, V Garsky, H Perry, S Bacchetti, R Colonno, R B Stein.   

Abstract

It has recently been reported that a nonapeptide (H-Tyr-Ala-Gly-Ala-Val-Val-Asn-Asp-Leu-OH) identical in sequence to the last nine amino acid residues of RR2, the small subunit of herpes simplex virus (HSV) ribonucleotide reductase (E.C. 1.17.4.1; RR), can inhibit HSV RR activity in vitro. It has been postulated that this peptide acts by interfering with the interaction of the large subunit, RR1, and RR2, but direct demonstration of its mechanism of action has not been reported. We present data which show that the inhibition of HSV RR by this oligopeptide is due to induced subunit dissociation.

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Year:  1988        PMID： 2827385     DOI： 10.1016/0042-6822(88)90421-7

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  12 in total

1.  Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir.

Authors:  D M Coen; D J Goldstein; S K Weller
Journal:  Antimicrob Agents Chemother       Date:  1989-08       Impact factor: 5.191

2.  The Epstein-Barr virus (EBV) deubiquitinating enzyme BPLF1 reduces EBV ribonucleotide reductase activity.

Authors:  Christopher B Whitehurst; Shunbin Ning; Gretchen L Bentz; Florent Dufour; Edward Gershburg; Julia Shackelford; Yves Langelier; Joseph S Pagano
Journal:  J Virol       Date:  2009-02-25       Impact factor: 5.103

3.  Resistance of herpes simplex virus type 1 to peptidomimetic ribonucleotide reductase inhibitors: selection and characterization of mutant isolates.

Authors:  A M Bonneau; P Kibler; P White; C Bousquet; N Dansereau; M G Cordingley
Journal:  J Virol       Date:  1996-02       Impact factor: 5.103

4.  Herpes simplex virus-encoded ribonucleotide reductase: evidence for the dissociation/reassociation of the holoenzyme.

Authors:  A J Darling; E M McKay; R Ingemarson; B Booth
Journal:  Virus Genes       Date:  1990-04       Impact factor: 2.332

5.  Reconstitution of herpes simplex virus type 1 ribonucleotide reductase activity from the large and small subunits.

Authors:  A J Darling; E M McKay; R Ingemarson; V G Preston
Journal:  Virus Genes       Date:  1989-03       Impact factor: 2.332

6.  Vaccinia virus-encoded ribonucleotide reductase subunits are differentially required for replication and pathogenesis.

Authors:  Don B Gammon; Branawan Gowrishankar; Sophie Duraffour; Graciela Andrei; Chris Upton; David H Evans
Journal:  PLoS Pathog       Date:  2010-07-08       Impact factor: 6.823

7.  Synthetic "interface" peptides alter dimeric assembly of the HIV 1 and 2 proteases.

Authors:  L M Babé; J Rosé; C S Craik
Journal:  Protein Sci       Date:  1992-10       Impact factor: 6.725

8.  Inhibition of herpes simplex virus type 1 DNA polymerase activity by peptides from the UL42 accessory protein is largely nonspecific.

Authors:  A M Owsianka; G Hart; M Murphy; J Gottlieb; R Boehme; M Challberg; H S Marsden
Journal:  J Virol       Date:  1993-01       Impact factor: 5.103

9.  Cloning, sequence determination, and regulation of the ribonucleotide reductase subunits from Plasmodium falciparum: a target for antimalarial therapy.

Authors:  H Rubin; J S Salem; L S Li; F D Yang; S Mama; Z M Wang; A Fisher; C S Hamann; B S Cooperman
Journal:  Proc Natl Acad Sci U S A       Date:  1993-10-15       Impact factor: 11.205

10.  Antiviral activity of a selective ribonucleotide reductase inhibitor against acyclovir-resistant herpes simplex virus type 1 in vivo.

Authors:  J Duan; M Liuzzi; W Paris; M Lambert; C Lawetz; N Moss; J Jaramillo; J Gauthier; R Déziel; M G Cordingley
Journal:  Antimicrob Agents Chemother       Date:  1998-07       Impact factor: 5.191
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