| Literature DB >> 28273451 |
Mauricio Medrano1, Laudine Communal2, Kevin R Brown3, Marcin Iwanicki4, Josee Normand5, Joshua Paterson5, Fabrice Sircoulomb5, Paul Krzyzanowski6, Marian Novak7, Sasha A Doodnauth1, Fernando Suarez Saiz5, Jane Cullis8, Rima Al-Awar6, Benjamin G Neel9, John McPherson6, Ronny Drapkin10, Laurie Ailles1, Anne-Marie Mes-Massons11, Robert Rottapel12.
Abstract
The degree of genetic aberrations characteristic of high-grade serous ovarian cancer (HGSC) makes identification of the molecular features that drive tumor progression difficult. Here, we perform genome-wide RNAi screens and comprehensive expression analysis of cell-surface markers in a panel of HGSC cell lines to identify genes that are critical to their survival. We report that the tetraspanin CD151 contributes to survival of a subset of HGSC cell lines associated with a ZEB transcriptional program and supports the growth of HGSC tumors. Moreover, we show that high CD151 expression is prognostic of poor clinical outcome. This study reveals cell-surface vulnerabilities associated with HGSC, provides a framework for identifying therapeutic targets, and reports a role for CD151 in HGSC.Entities:
Keywords: CD151; RNAi screen; cell-surface; high-grade serous ovarian cancer; mesenchymal subtype
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Year: 2017 PMID： 28273451 DOI： 10.1016/j.celrep.2017.02.028
Source DB: PubMed Journal: Cell Rep Impact factor: 9.423