Maryam Kashanian1, Seyyedeh Samaneh Mohtashami1, Mohammad Hassan Bemanian2, Seyyed Ali Javad Moosavi3, Maziar Moradi Lakeh4. 1. Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Akbarabadi Teaching Hospital, Tehran, Iran. 2. Department of Pediatrics, Iran University of Medical Sciences, Hazrate Rasool Akram Teaching Hospital, Tehran, Iran. 3. Department of Internal Medicine, Iran University of Medical Sciences, Hazrate Rasool Akram Teaching Hospital, Tehran, Iran. 4. Department of Community Medicine, Iran University of Medical Sciences, Tehran, Iran.
Abstract
OBJECTIVE: To identify prenatal and perinatal risk factors for childhood asthma. METHODS: A retrospective case-control study was undertaken among children aged 7-14 years in Tehran, Iran, between March 2009 and November 2014. Data for children with asthma (Iranian nationality, non-smoking parents, and middle-class socioeconomic status) were compared with those for an equal number of age- and sex-matched non-asthmatic children. Prenatal and perinatal risk factors were evaluated via complete data sheets of maternal pregnancy and delivery. Forward logistic regression analysis was performed. RESULTS: Both groups contained 134 children. Risk of asthma was shown to be associated with maternal history of asthma (adjusted odds ratio [aOR] 11.62, 95% confidence interval 1.38-96.93; P=0.024), vaginal bleeding during pregnancy (aOR 3.76, 95% CI 1.86-7.57; P<0.001), antibiotics during pregnancy (aOR 3.19, 95% CI 1.52-6.67; P=0.002), and maternal age 30 years or older (aOR 2.54, 95% CI 1.30-4.95; P=0.006). Breastfeeding was protective against childhood asthma (aOR 0.29, 95% CI 0.151-0.575; P<0.001). CONCLUSION: History of maternal asthma was the most influential factor on development of childhood asthma, followed by vaginal bleeding during pregnancy, antibiotic exposure in utero, and older maternal age.
OBJECTIVE: To identify prenatal and perinatal risk factors for childhood asthma. METHODS: A retrospective case-control study was undertaken among children aged 7-14 years in Tehran, Iran, between March 2009 and November 2014. Data for children with asthma (Iranian nationality, non-smoking parents, and middle-class socioeconomic status) were compared with those for an equal number of age- and sex-matched non-asthmatic children. Prenatal and perinatal risk factors were evaluated via complete data sheets of maternal pregnancy and delivery. Forward logistic regression analysis was performed. RESULTS: Both groups contained 134 children. Risk of asthma was shown to be associated with maternal history of asthma (adjusted odds ratio [aOR] 11.62, 95% confidence interval 1.38-96.93; P=0.024), vaginal bleeding during pregnancy (aOR 3.76, 95% CI 1.86-7.57; P<0.001), antibiotics during pregnancy (aOR 3.19, 95% CI 1.52-6.67; P=0.002), and maternal age 30 years or older (aOR 2.54, 95% CI 1.30-4.95; P=0.006). Breastfeeding was protective against childhood asthma (aOR 0.29, 95% CI 0.151-0.575; P<0.001). CONCLUSION: History of maternal asthma was the most influential factor on development of childhood asthma, followed by vaginal bleeding during pregnancy, antibiotic exposure in utero, and older maternal age.
Authors: Brooks W Morgan; Trishul Siddharthan; Matthew R Grigsby; Suzanne L Pollard; Robert Kalyesubula; Robert A Wise; Bruce Kirenga; William Checkley Journal: J Allergy Clin Immunol Pract Date: 2018-02-01
Authors: Daniel Munblit; Diego G Peroni; Alba Boix-Amorós; Peter S Hsu; Belinda Van't Land; Melvin C L Gay; Anastasia Kolotilina; Chrysanthi Skevaki; Robert J Boyle; Maria Carmen Collado; Johan Garssen; Donna T Geddes; Ralph Nanan; Carolyn Slupsky; Ganesa Wegienka; Anita L Kozyrskyj; John O Warner Journal: Nutrients Date: 2017-08-17 Impact factor: 5.717