Literature DB >> 28272917

Candidate Gene Analysis of Breast Cancer in the Jordanian Population of Arab Descent: A Case-Control Study.

Laith N Al-Eitan1,2, Reem I Jamous1,2, Rame H Khasawneh3.   

Abstract

This study aimed to investigate whether there are specific polymorphisms within six genes (BRCA1, BRCA2, TP53, DAPK1, MMP9 promoter, and TOX3) that are associated with breast cancer among the Jordanian population. Sequenom MassARRAY system was used to genotype 17 single nucleotide polymorphisms (SNPs) within these genes in 230 Jordanian breast cancer patients and 225 healthy individuals. Three SNPs (MMP9 (rs6065912), TOX3 (rs1420546), and DAPK1 (rs11141901) were found to be significantly associated with an increased risk of breast cancer (p < .05). This study is the first to provide evidence that genetic variation in MMP9, TOX3, and DAPK1 genes contribute to the development of breast cancer in the Jordanian population.

Entities:  

Keywords:  Breast cancer; Jordanian Arabs; case-control study; genetic association

Mesh：

Year:  2017        PMID： 28272917     DOI： 10.1080/07357907.2017.1289217

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  10 in total

Review 1.  Familial/inherited cancer syndrome: a focus on the highly consanguineous Arab population.

Authors:  Fawz S AlHarthi; Alya Qari; Alaa Edress; Malak Abedalthagafi
Journal:  NPJ Genom Med       Date:  2020-02-03       Impact factor: 8.617

2.  Associations of BNIP3 and DAPK1 gene polymorphisms with disease susceptibility, clinicopathologic features, anxiety, and depression in gastric cancer patients.

Authors:  Xiaoqi Lou; Dingtao Hu; Zhen Li; Ying Teng; Qiuyue Lou; Shunwei Huang; Yanfeng Zou; Fang Wang
Journal:  Int J Clin Exp Pathol       Date:  2021-05-15

3.  The influence of an IL-4 variable number tandem repeat (VNTR) polymorphism on breast cancer susceptibility.

Authors:  Laith N Al-Eitan; Doaa M Rababa'h; Mansour A Alghamdi; Rame H Khasawneh
Journal:  Pharmgenomics Pers Med       Date:  2019-08-26

4.  Family specific genetic predisposition to breast cancer: results from Tunisian whole exome sequenced breast cancer cases.

Authors:  Yosr Hamdi; Maroua Boujemaa; Mariem Ben Rekaya; Cherif Ben Hamda; Najah Mighri; Houda El Benna; Nesrine Mejri; Soumaya Labidi; Nouha Daoud; Chokri Naouali; Olfa Messaoud; Mariem Chargui; Kais Ghedira; Mohamed Samir Boubaker; Ridha Mrad; Hamouda Boussen; Sonia Abdelhak
Journal:  J Transl Med       Date:  2018-06-07       Impact factor: 5.531

5.  Association of CYP gene polymorphisms with breast cancer risk and prognostic factors in the Jordanian population.

Authors:  Laith N Al-Eitan; Doaa M Rababa'h; Mansour A Alghamdi; Rame H Khasawneh
Journal:  BMC Med Genet       Date:  2019-09-02       Impact factor: 2.103

6.  Association Of GSTM1, GSTT1 And GSTP1 Polymorphisms With Breast Cancer Among Jordanian Women.

Authors:  Laith N Al-Eitan; Doaa M Rababa'h; Mansour A Alghamdi; Rame H Khasawneh
Journal:  Onco Targets Ther       Date:  2019-09-20       Impact factor: 4.147

Review 7.  Familial/inherited cancer syndrome: a focus on the highly consanguineous Arab population.

Authors:  Fawz S AlHarthi; Alya Qari; Alaa Edress; Malak Abedalthagafi
Journal:  NPJ Genom Med       Date:  2020-02-03       Impact factor: 8.617

8.  The Association of IL-1 and HRAS Gene Polymorphisms with Breast Cancer Susceptibility in a Jordanian Population of Arab Descent: A Genotype-Phenotype Study.

Authors:  Laith N Al-Eitan; Bashar H Al-Ahmad; Fouad A Almomani
Journal:  Cancers (Basel)       Date:  2020-01-23       Impact factor: 6.639

9.  Association between ESR1, ESR2, HER2, UGT1A4, and UGT2B7 polymorphisms and breast Cancer in Jordan: a case-control study.

Authors:  Laith N Al-Eitan; Doaa M Rababa'h; Mansour A Alghamdi; Rame H Khasawneh
Journal:  BMC Cancer       Date:  2019-12-30       Impact factor: 4.430

10.  The Associations of Common Genetic Susceptibility Variants with Breast Cancer in Jordanian Arabs: A Case-Control Study.

Authors:  Laith N Al-Eitan; Doaa M Rababa'h; Hatem A Aman
Journal:  Asian Pac J Cancer Prev       Date:  2020-10-01
  10 in total

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