Literature DB >> 28267457

Imaging of Prostate Cancer Using Urokinase-Type Plasminogen Activator Receptor PET.

Dorthe Skovgaard1, Morten Persson2, Andreas Kjaer3.   

Abstract

Urokinase-type plasminogen activator receptor (uPAR) overexpression is an important biomarker for aggressiveness in cancer including prostate cancer (PC) and provides independent clinical information in addition to prostate-specific antigen and Gleason score. This article focuses on uPAR PET as a new diagnostic and prognostic imaging biomarker in PC. Many preclinical uPAR-targeted PET imaging studies using AE105 in cancer models have been undertaken with promising results. A major breakthrough was obtained with the recent human translation of uPAR PET in using 64Cu- and 68Ga-labelled versions of AE105, respectively. Clinical results from patients with PC included in these studies are encouraging and support continuation with large-scale clinical trials.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Molecular imaging; PET; Prostate cancer; Radionuclide imaging; Theranostics; uPAR

Mesh：

Substances：

Year:  2017        PMID： 28267457     DOI： 10.1016/j.cpet.2016.12.005

Source DB:  PubMed          Journal:  PET Clin        ISSN： 1556-8598


  5 in total

1.  Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer.

Authors:  Larry Fliegel
Journal:  Rev Physiol Biochem Pharmacol       Date:  2022       Impact factor: 5.545

2.  Prognostic Value of Urokinase-Type Plasminogen Activator Receptor PET/CT in Head and Neck Squamous Cell Carcinomas and Comparison with 18F-FDG PET/CT: A Single-Center Prospective Study.

Authors:  Louise M Risør; Malene M Clausen; Zaza Ujmajuridze; Mohammed Farhadi; Kim F Andersen; Annika Loft; Jeppe Friborg; Andreas Kjaer
Journal:  J Nucl Med       Date:  2021-12-02       Impact factor: 11.082

3.  Surface Modification of Liposomes by a Lipopolymer Targeting Prostate Specific Membrane Antigen for Theranostic Delivery in Prostate Cancer.

Authors:  Hooman Yari; Gregory Nkepang; Vibhudutta Awasthi
Journal:  Materials (Basel)       Date:  2019-03-05       Impact factor: 3.623

Review 4.  A Comprehensive Review of Non-Covalent Radiofluorination Approaches Using Aluminum [18F]fluoride: Will [18F]AlF Replace 68Ga for Metal Chelate Labeling?

Authors:  Cyril Fersing; Ahlem Bouhlel; Christophe Cantelli; Philippe Garrigue; Vincent Lisowski; Benjamin Guillet
Journal:  Molecules       Date:  2019-08-07       Impact factor: 4.411

Review 5.  Molecular imaging of the urokinase plasminogen activator receptor: opportunities beyond cancer.

Authors:  V M Baart; R D Houvast; L F de Geus-Oei; P H A Quax; P J K Kuppen; A L Vahrmeijer; C F M Sier
Journal:  EJNMMI Res       Date:  2020-07-28       Impact factor: 3.138
  5 in total

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