| Literature DB >> 28266673 |
David A Price1, Heather Eng, Kathleen A Farley, Gilles H Goetz, Yong Huang, Zhaodong Jiao, Amit S Kalgutkar, Natasha M Kablaoui, Bhagyashree Khunte, Spiros Liras, Chris Limberakis, Alan M Mathiowetz, Roger B Ruggeri, Jun-Min Quan, Zhen Yang.
Abstract
The synthesis and in vivo pharmacokinetic profile of an analogue of cyclosporine is disclosed. An acyclic congener was also profiled in in vitro assays to compare cell permeability. The compounds possess similar calculated and measured molecular descriptors however have different behaviors in an RRCK assay to assess cell permeability.Entities:
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Year: 2017 PMID： 28266673 DOI： 10.1039/c7ob00096k
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876