Literature DB >> 28264136

Phototherapeutic Keratectomy: Science and Art.

Steven E Wilson, Gustavo K Marino, Carla S Medeiros, Marcony R Santhiago.   

Abstract

PURPOSE: To describe, with videos, the principles of excimer laser phototherapeutic keratectomy (PTK) for the treatment of corneal scars, corneal surface irregularity, and recurrent corneal erosions.
METHODS: Depending on the pathology in a treated cornea, the epithelium is removed either by transepithelial PTK ablation with the excimer laser or thorough scraping with a scalpel blade. Stromal PTK can be performed with or without photorefractive keratectomy (PRK), depending on the refractive status of both eyes. Residual surface irregularity is treated with masking-smoothing PTK. Typically, 0.02% mitomycin C treatment is applied for 30 seconds to corneas treated with PTK for scars and surface irregularity.
RESULTS: Transepithelial PTK with masking-smoothing typically improves corrected distance visual acuity in the eye even if the entire stromal opacity cannot be removed and can be used to debulk surface irregularity to facilitate subsequent therapeutic customized wavefront-guided or optical coherence tomography-guided PTK or PRK. PTK for recurrent erosion is performed after thorough mechanical epithelial debridement of redundant epithelial basement membrane (EBM) with a scalpel and should only include a dusting of excimer laser to remove residual EBM without inducing central irregular astigmatism or damaging limbal tissues. Meta-analyses are provided for PTK treatment for corneal scars, corneal dystrophies, and recurrent corneal erosions.
CONCLUSIONS: Excimer laser PTK is a highly effective treatment for superficial corneal scars, central corneal irregular astigmatism, and recurrent corneal erosions unresponsive to medical treatment or mechanical epithelial debridement alone. [J Refract Surg. 2017;33(3):203-210.]. Copyright 2017, SLACK Incorporated.

Entities:  

Mesh:

Year:  2017        PMID: 28264136     DOI: 10.3928/1081597X-20161123-01

Source DB:  PubMed          Journal:  J Refract Surg        ISSN: 1081-597X            Impact factor:   3.573


  8 in total

1.  Pathophysiology of Corneal Scarring in Persistent Epithelial Defects After PRK and Other Corneal Injuries.

Authors:  Steven E Wilson; Carla S Medeiros; Marcony R Santhiago
Journal:  J Refract Surg       Date:  2018-01-01       Impact factor: 3.573

Review 2.  Coordinated Modulation of Corneal Scarring by the Epithelial Basement Membrane and Descemet's Basement Membrane.

Authors:  Steven E Wilson
Journal:  J Refract Surg       Date:  2019-08-01       Impact factor: 3.573

3.  Epithelial Basement Membrane Regeneration After PRK-Induced Epithelial-Stromal Injury in Rabbits: Fibrotic Versus Non-fibrotic Corneal Healing.

Authors:  Rodrigo Carlos de Oliveira; Lycia Pedral Sampaio; Thomas Michael Shiju; Marcony R Santhiago; Steven E Wilson
Journal:  J Refract Surg       Date:  2022-01-01       Impact factor: 3.573

Review 4.  The Corneal Basement Membranes and Stromal Fibrosis.

Authors:  Carla S Medeiros; Gustavo K Marino; Marcony R Santhiago; Steven E Wilson
Journal:  Invest Ophthalmol Vis Sci       Date:  2018-08-01       Impact factor: 4.799

5.  Oral l-Cysteine Supplementation Enhances the Long Term-Effect of Topical Basic Fibroblast Growth Factor (bFGF) in Reducing the Corneal Haze after Photorefractive Keratectomy in Myopic Patients.

Authors:  Alessandro Meduri; Loredana Bergandi; Pietro Perroni; Francesca Silvagno; Pasquale Aragona
Journal:  Pharmaceuticals (Basel)       Date:  2020-04-15

6.  Phototherapeutic keratectomy: Indications, methods and decision making.

Authors:  Rashmi Deshmukh; Jagadesh C Reddy; Christopher J Rapuano; Pravin K Vaddavalli
Journal:  Indian J Ophthalmol       Date:  2020-12       Impact factor: 1.848

7.  Combined Phototherapeutic Keratectomy and Peripheral Anterior Stromal Puncture for the Treatment of Recurrent Corneal Erosion Syndrome.

Authors:  Mi Yeon Song; Jae Lim Chung; Kook Young Kim; Kyu Yeon Hwang; Young A Kwon; Sang Wroul Song; Byung Yeop Kim; Kyungmin Koh
Journal:  Korean J Ophthalmol       Date:  2020-08

8.  Salzmann nodular degeneration in posterior keratoconus: a case report.

Authors:  Peng Song; Xiaofei Yu; Chenjiu Pang
Journal:  BMC Ophthalmol       Date:  2022-03-12       Impact factor: 2.209

  8 in total

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