Literature DB >> 2826310

Effect of a transplantable insulinoma upon serotonin concentrations in the intestine of the rat.

J M Conlon1, C J Bailey, P R Flatt.   

Abstract

Rapid growth of a transplantable insulinoma in rats over a 14 day period results in hyperphagia together with a selective increase in the weight and enteroglucagon (GLI) concentration of the small intestine. Measurement of serotonin concentrations by an HPLC/fluorometric method demonstrated an increase in blood (91%; p less than 0.05) and in extracts of colon (22%; p less than 0.05) but no change in extracts of the small intestine and caecum. The data support the hypothesis that the rise in enteroglucagon is related directly to the growth of the small intestine and is not a non-specific effect of hyperphagia.

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Year:  1987        PMID： 2826310      PMCID： PMC1434557          DOI： 10.1136/gut.28.suppl.213

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  13 in total

Review 1.  The tropic action of gastro-intestinal hormones.

Authors:  J A Barrowman
Journal:  Digestion       Date:  1975       Impact factor: 3.216

2.  Pancreatic islets: a tissue rich in serotonin.

Authors:  J L Bird; E E Wright; J M Feldman
Journal:  Diabetes       Date:  1980-04       Impact factor: 9.461

3.  Monoamines in the pancreatic islets of the mouse. Subcellular localization of 5-hydroxytryptamine by electron microscopic autoradiography.

Authors:  R Ekholm; L E Ericson; I Lundquist
Journal:  Diabetologia       Date:  1971-10       Impact factor: 10.122

4.  Endocrine tumour in kidney affecting small bowel structure, motility, and absorptive function.

Authors:  M H Gleeson; S R Bloom; J M Polak; K Henry; R H Dowling
Journal:  Gut       Date:  1971-10       Impact factor: 23.059

5.  A transplantable insulinoma in the rat.

Authors:  W L Chick; S Warren; R N Chute; A A Like; V Lauris; K C Kitchen
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

6.  Regulation of serotonin release from rabbit intestinal enterochromaffin cells.

Authors:  E J Forsberg; R J Miller
Journal:  J Pharmacol Exp Ther       Date:  1983-12       Impact factor: 4.030

7.  Serotonin-induced alteration of colonic electrolyte transport in the rat.

Authors:  T W Zimmerman; H J Binder
Journal:  Gastroenterology       Date:  1984-02       Impact factor: 22.682

8.  Fluorometric detection of tryptophan, 5-hydroxytryptophan, and 5-hydroxytryptamine (serotonin) in high-performance liquid chromatography.

Authors:  T Flatmark; S W Jacobsen; J Haavik
Journal:  Anal Biochem       Date:  1980-09-01       Impact factor: 3.365

9.  Evolution of glucagon genes.

Authors:  L C Lopez; W H Li; M L Frazier; C C Luo; G F Saunders
Journal:  Mol Biol Evol       Date:  1984-07       Impact factor: 16.240

10.  Changes in the somatostatin, substance P and vasoactive intestinal polypeptide content of the gastrointestinal tract following streptozotocin-induced diabetes in the rat.

Authors:  M Ballmann; J M Conlon
Journal:  Diabetologia       Date:  1985-06       Impact factor: 10.122
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