Literature DB >> 2826296

Pseudorabies virus as a live virus vector for expression of foreign genes.

D R Thomsen1, K R Marotti, D P Palermo, L E Post.   

Abstract

The cDNA coding for human tissue plasminogen activator (tPA) was cloned downstream from the promoter for pseudorabies virus (PRV) glycoprotein and flanked by downstream PRV DNA. After co-transfection with PRV DNA, this plasmid recombined to insert the tPA cDNA into the viral genome. In cells infected by this recombinant virus, tPA was detected by immunoprecipitation analysis and by enzymatic activity. Since it has a wide host range but does not infect humans, PRV is a possible vaccine vector for genes from animal pathogens.

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Year:  1987        PMID： 2826296     DOI： 10.1016/0378-1119(87)90130-2

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  12 in total

1.  Identification and DNA sequence analysis of the Marek's disease virus serotype 2 genes homologous to the thymidine kinase and UL24 genes of herpes simplex virus type 1.

Authors:  Y Shimojima; H K Jang; M Ono; K Maeda; Y Tohya; T Mikami
Journal:  Virus Genes       Date:  1997       Impact factor: 2.332

2.  Identification and nucleotide sequence of the thymidine kinase gene of canine herpesvirus.

Authors:  X Xuan; K Maeda; Y Tohya; T Mikami; H Otsuka
Journal:  Virus Genes       Date:  1996       Impact factor: 2.332

3.  Pseudorabies virus recombinants expressing functional virulence determinants gE and gI from bovine herpesvirus 1.1.

Authors:  A C Knapp; L W Enquist
Journal:  J Virol       Date:  1997-04       Impact factor: 5.103

4.  Recombinant feline herpesviruses expressing feline leukemia virus envelope and gag proteins.

Authors:  G E Cole; S Stacy-Phipps; J H Nunberg
Journal:  J Virol       Date:  1990-10       Impact factor: 5.103

5.  Glycoprotein gp50-negative pseudorabies virus: a novel approach toward a nonspreading live herpesvirus vaccine.

Authors:  S Heffner; F Kovács; B G Klupp; T C Mettenleiter
Journal:  J Virol       Date:  1993-03       Impact factor: 5.103

6.  Live attenuated pseudorabies virus expressing envelope glycoprotein E1 of hog cholera virus protects swine against both pseudorabies and hog cholera.

Authors:  M van Zijl; G Wensvoort; E de Kluyver; M Hulst; H van der Gulden; A Gielkens; A Berns; R Moormann
Journal:  J Virol       Date:  1991-05       Impact factor: 5.103

7.  A herpesvirus vector for expression of glycosylated membrane antigens: fusion proteins of pseudorabies virus gIII and human immunodeficiency virus type 1 envelope glycoproteins.

Authors:  M E Whealy; K Baumeister; A K Robbins; L W Enquist
Journal:  J Virol       Date:  1988-11       Impact factor: 5.103

8.  Identification of the thymidine kinase gene of feline herpesvirus: use of degenerate oligonucleotides in the polymerase chain reaction to isolate herpesvirus gene homologs.

Authors:  J H Nunberg; D K Wright; G E Cole; E A Petrovskis; L E Post; T Compton; J H Gilbert
Journal:  J Virol       Date:  1989-08       Impact factor: 5.103

9.  Expression of porcine pseudorabies virus genes by a bovine herpesvirus-1 (infectious bovine rhinotracheitis virus) vector.

Authors:  S Kit; H Otsuka; M Kit
Journal:  Arch Virol       Date:  1992       Impact factor: 2.574

10.  Loop-mediated isothermal amplification for rapid detection and differentiation of wild-type pseudorabies and gene-deleted virus vaccines.

Authors:  Chao-Fan Zhang; Shang-Jin Cui; Chao Zhu
Journal:  J Virol Methods       Date:  2010-08-04       Impact factor: 2.014
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