Protein factor that inhibits binding and promotes release of androgen-receptor complex from nuclear chromatin.

A protein factor that can inhibit binding of the androgen-receptor complex to the nuclear chromatin has been isolated from the cytosol of the ventral prostate of rats. The inhibition is reversible and not caused by an irreversible destruction of the receptor or the chromatin. The inhibitor also can promote, by a temperature-dependent process, the release of steroid-receptor complex already bound to chromatin. It is conceivable that such a protein factor plays a regulatory role in the nuclear-cytoplasmic recycling or chromatin binding of the steroid hormone receptor.