Meredith Johnson1, Yue Chen1, Sierra Hovet1, Sheng Xu2, Bradford Wood2, Hongliang Ren3, Junichi Tokuda4, Zion Tsz Ho Tse5. 1. College of Engineering, The University of Georgia, Athens, GA, 30605, USA. 2. National Institutes of Health, Bethesda, MD, USA. 3. Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore. 4. Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 5. College of Engineering, The University of Georgia, Athens, GA, 30605, USA. ziontse@uga.edu.
Abstract
PURPOSE: Origami-based biomedical device design is an emerging technology due to its ability to be deployed from a minimal foldable pattern to a larger volume. This paper aims to review state-of-the-art origami structures applied in the medical device field. METHODS: Publications and reports of origami structure related to medical device design from the past 10 years are reviewed and categorized according to engineering specifications, including the application field, fabrication material, size/volume, deployment method, manufacturability, and advantages. RESULTS: This paper presents an overview of the biomedical applications of devices based on origami structures, including disposable sterilization covers, cardiac catheterization, stent grafts, encapsulation and microsurgery, gastrointestinal microsurgery, laparoscopic surgical grippers, microgrippers, microfluidic devices, and drug delivery. Challenges in terms of materials and fabrication, assembly, modeling and computation design, and clinical adoptability are discussed at the end of this paper to provide guidance for future origami-based design in the medical device field. CONCLUSION: Concepts from origami can be used to design and develop novel medical devices. Origami-based medical device design is currently progressing, with researchers improving design methods, materials, fabrication techniques, and folding efficiency.
PURPOSE:Origami-based biomedical device design is an emerging technology due to its ability to be deployed from a minimal foldable pattern to a larger volume. This paper aims to review state-of-the-art origami structures applied in the medical device field. METHODS: Publications and reports of origami structure related to medical device design from the past 10 years are reviewed and categorized according to engineering specifications, including the application field, fabrication material, size/volume, deployment method, manufacturability, and advantages. RESULTS: This paper presents an overview of the biomedical applications of devices based on origami structures, including disposable sterilization covers, cardiac catheterization, stent grafts, encapsulation and microsurgery, gastrointestinal microsurgery, laparoscopic surgical grippers, microgrippers, microfluidic devices, and drug delivery. Challenges in terms of materials and fabrication, assembly, modeling and computation design, and clinical adoptability are discussed at the end of this paper to provide guidance for future origami-based design in the medical device field. CONCLUSION: Concepts from origami can be used to design and develop novel medical devices. Origami-based medical device design is currently progressing, with researchers improving design methods, materials, fabrication techniques, and folding efficiency.
Entities:
Keywords:
Biomaterials.; Biomedical; Origami; Paper folding; Surgical
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