| Literature DB >> 28260080 |
Ping Luo1, Gaixia Lu2, Lin-Lin Fan3, Xiaoming Zhong4, Huiqiong Yang2, Ruting Xie2, Zhongwei Lv2, Qian-Zhou Lv3, Da Fu2, Li-Xin Yang5, Yushui Ma2.
Abstract
The present study was carried out to investigate the clinical significance of TMPRSS3 and TNFRSF11B in breast cancer. Thus, the expression levels of TMPRSS3 and TNFRSF11B and the correlation with prognosis in patients with breast cancer were analyzed in silico using gene microarray and hierarchical clustering analysis. Then, the differential expression in breast cancer vs. normal breast tissue was explored in the Oncomine platform and verified in our independent samples using IHC technique. Our results indicated that TMPRSS3 was upregulated and TNFRSF11B was downregulated in breast cancer tissues compared with the levels in the human normal breast tissues. TMPRSS3 and TNFRSF11B were confirmed to be correlated with distant organ metastasis of breast cancer. Moreover, upregulation of TMPRSS3 accompanied by downregulation of TNFRSF11B was found to be associated with a shorter median overall survival and indicated a poor prognosis. In conclusion, TMPRSS3 and TNFRSF11B may have potential prognostic value to be used as tumor biomarkers in breast cancer patients.Entities:
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Year: 2017 PMID： 28260080 DOI： 10.3892/or.2017.5449
Source DB: PubMed Journal: Oncol Rep ISSN： 1021-335X Impact factor: 3.906