BACKGROUND: Congenital cytomegalovirus (cCMV) infections are the most prevalent intrauterine infections worldwide and are the result of maternal primary or non-primary infections. Early maternal primary infections are thought to carry the highest risk of fetal developmental abnormalities as seen by ultrasound; however, non-primary infections may prove equally detrimental. METHODS/ RESULTS: This case series presents 5 cases with fetal abnormalities detected in the second and third trimester, in which cCMV infection was ruled out due to negative maternal CMV-IgM. DISCUSSION: This series highlights the possible pitfalls in serology interpretation and fetal diagnosis necessary for appropriate parental counseling. Once fetal abnormalities have been confirmed and cCMV is suspected, maternal CMV serostatus and fetal infection should be determined. Maternal CMV serology may be ambiguous; therefore, caution should be exercised when interpreting the results.
BACKGROUND: Congenital cytomegalovirus (cCMV) infections are the most prevalent intrauterine infections worldwide and are the result of maternal primary or non-primary infections. Early maternal primary infections are thought to carry the highest risk of fetal developmental abnormalities as seen by ultrasound; however, non-primary infections may prove equally detrimental. METHODS/ RESULTS: This case series presents 5 cases with fetal abnormalities detected in the second and third trimester, in which cCMV infection was ruled out due to negative maternal CMV-IgM. DISCUSSION: This series highlights the possible pitfalls in serology interpretation and fetal diagnosis necessary for appropriate parental counseling. Once fetal abnormalities have been confirmed and cCMV is suspected, maternal CMV serostatus and fetal infection should be determined. Maternal CMV serology may be ambiguous; therefore, caution should be exercised when interpreting the results.
Authors: Natanja Oosterom; Joppe Nijman; Julia Gunkel; Tom F W Wolfs; Floris Groenendaal; Malgosia A Verboon-Maciolek; Linda S de Vries Journal: Neonatology Date: 2015-03-10 Impact factor: 4.035
Authors: A M H Korver; J J C de Vries; J W de Jong; F W Dekker; A C T M Vossen; A M Oudesluys-Murphy Journal: J Clin Virol Date: 2009-10-08 Impact factor: 3.168
Authors: Monique T R Pereboom; Judith Manniën; Kelly D J van Almkerk; Evelien R Spelten; Janneke T Gitsels; Linda Martin; Eileen K Hutton; François G Schellevis Journal: Patient Educ Couns Date: 2014-04-21
Authors: O Picone; N Teissier; A G Cordier; C Vauloup-Fellous; H Adle-Biassette; J Martinovic; M V Senat; J M Ayoubi; A Benachi Journal: Prenat Diagn Date: 2014-03-18 Impact factor: 3.050