| Literature DB >> 28259645 |
Virginie Neirinckx1, Hakan Hedman2, Simone P Niclou3.
Abstract
Leucine-rich repeats and immunoglobulin-like domains containing protein 1 (LRIG1) is an endogenous feedback regulator of receptor tyrosine kinases (RTKs) and was recently shown to inhibit growth of different types of malignancies. Additionally, this multifaceted RTK inhibitor was reported to be a tumor suppressor, a stem cell regulator, and a modulator of different cellular phenotypes. This mini-review provides a concise and up-to-date summary about the known functions of LRIG1 and its related family members, with a special emphasis on underlying molecular mechanisms and the opportunities for harnessing its therapeutic potential against cancer.Entities:
Keywords: Cancer; Ectodomain; Leucine-rich repeats and immunoglobulin-like domains containing protein 1; Nervous system; Receptor tyrosine kinase
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Year: 2017 PMID： 28259645 DOI： 10.1016/j.bbcan.2017.02.007
Source DB: PubMed Journal: Biochim Biophys Acta Rev Cancer ISSN： 0304-419X Impact factor: 10.680