Uffe Bernchou1, Rasmus Lübeck Christiansen2, Jon Thor Asmussen3, Tine Schytte4, Olfred Hansen5, Carsten Brink6. 1. Institute of Clinical Research, University of Southern Denmark, Odense, Denmark; Laboratory of Radiation Physics, Odense University Hospital, Odense, Denmark. Electronic address: uffe.bernchou@rsyd.dk. 2. Laboratory of Radiation Physics, Odense University Hospital, Odense, Denmark. 3. Department of Radiology, Odense University Hospital, Odense, Denmark. 4. Department of Oncology, Odense University Hospital, Odense, Denmark. 5. Institute of Clinical Research, University of Southern Denmark, Odense, Denmark; Department of Oncology, Odense University Hospital, Odense, Denmark. 6. Institute of Clinical Research, University of Southern Denmark, Odense, Denmark; Laboratory of Radiation Physics, Odense University Hospital, Odense, Denmark.
Abstract
BACKGROUND AND PURPOSE: The present study investigates the extent and appearance of radiologic injury in the lung after radiotherapy for non-small cell lung cancer (NSCLC) patients and correlates radiologic response with clinical and dosimetric factors. METHODS AND MATERIALS: Eligible follow-up CT scans acquired up to six months after radiotherapy were evaluated for radiologic injuries in 220 NSCLC patients. Radiologic injuries were divided into three categories: (1) interstitial changes, (2) ground-glass opacity, or (3) consolidation. The relationship between the fraction of injured lung of each category and clinical or dosimetric factors was investigated. RESULTS: Radiological injuries of category 1-3 were found in 67%, 52%, and 51% of the patients, and the mean (and maximum) fraction of injured lung was 4.4% (85.9%), 2.4% (46.0%), and 2.1% (22.9%), respectively. Traditional lung dose metrics and time to follow-up predicted lung injury of all categories. Older age increased the risk of interstitial changes and current smoking reduced the risk of consolidation in the lung. CONCLUSION: Radiologic injuries were frequently found in follow-up CT scans after radiotherapy for NSCLC patients. The risk of a radiologic response increased with increasing time and lung dose metrics, and depended on patient age and smoking status.
BACKGROUND AND PURPOSE: The present study investigates the extent and appearance of radiologic injury in the lung after radiotherapy for non-small cell lung cancer (NSCLC) patients and correlates radiologic response with clinical and dosimetric factors. METHODS AND MATERIALS: Eligible follow-up CT scans acquired up to six months after radiotherapy were evaluated for radiologic injuries in 220 NSCLCpatients. Radiologic injuries were divided into three categories: (1) interstitial changes, (2) ground-glass opacity, or (3) consolidation. The relationship between the fraction of injured lung of each category and clinical or dosimetric factors was investigated. RESULTS: Radiological injuries of category 1-3 were found in 67%, 52%, and 51% of the patients, and the mean (and maximum) fraction of injured lung was 4.4% (85.9%), 2.4% (46.0%), and 2.1% (22.9%), respectively. Traditional lung dose metrics and time to follow-up predicted lung injury of all categories. Older age increased the risk of interstitial changes and current smoking reduced the risk of consolidation in the lung. CONCLUSION: Radiologic injuries were frequently found in follow-up CT scans after radiotherapy for NSCLCpatients. The risk of a radiologic response increased with increasing time and lung dose metrics, and depended on patient age and smoking status.
Authors: Catarina Veiga; Edward Chandy; Joseph Jacob; Natalie Yip; Adam Szmul; David Landau; Jamie R McClelland Journal: Radiother Oncol Date: 2020-03-30 Impact factor: 6.280
Authors: Edward Chandy; Adam Szmul; Alkisti Stavropoulou; Joseph Jacob; Catarina Veiga; David Landau; James Wilson; Sarah Gulliford; John D Fenwick; Maria A Hawkins; Crispin Hiley; Jamie R McClelland Journal: Cancers (Basel) Date: 2022-02-14 Impact factor: 6.639