Tao He1, Jie Wang2, Xiao-Li Wang3, Wen-Shuai Deng1, Peng Sun4. 1. Department of Neurosurgery, Affiliated Hospital of Qingdao University, Qingdao, China. 2. Department of Gerontology, Affiliated Hospital of Qingdao University, Qingdao, China. 3. Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China. 4. Department of Neurosurgery, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address: 123022647@qq.com.
Abstract
BACKGROUND: In recent years, dozens of case-control studies showed that matrix metalloproteinase (MMP)-9 rs3918242 variants were associated with ischemic stroke (IS) susceptibility. However, the conclusions of case-control studies that evaluated the relationship between MMP-9 rs3918242 variants and the risk of IS were still equivocal. Herein, we conducted a comprehensive meta-analysis to investigate the association between MMP-9 rs3918242 variants and the risk of IS. METHODS: We searched 5 databases (PubMed, EMBASE, Google Scholar, Web of Science, and Chinese Biomedical Literature Database) to identify the eligible studies up to October of 2016. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association of MMP-9 rs3918242 variants with IS susceptibility under the allelic model (T versus C) and the dominant model (TT + CT versus CC). RESULTS: A total of 14 studies with 3233 cases and 3123 controls were included in this meta-analysis. Our meta-analysis indicated that MMP-9 rs3918242 variants were associated with significantly increased risk of IS in overall populations (T versus C: OR = 1.43, 95% CI = 1.20-1.71, P < .001; TT + CT versus CC: OR = 1.39, 95% CI = 1.16-1.67, P < .001). Subgroup analysis based on ethnicity (Chinese and Caucasian) suggested that MMP-9 rs3918242 variants contributed to increase the risk of IS in Chinese population; However, no association was detected between MMP-9 rs3918242 variants and the risk of IS in Caucasian population. CONCLUSION: Therefore, our meta-analysis suggested that MMP-9 rs3918242 variants (T allele, TT and CT genotypes) contributed to significantly increase the risk of IS in the Chinese population.
BACKGROUND: In recent years, dozens of case-control studies showed that matrix metalloproteinase (MMP)-9rs3918242 variants were associated with ischemic stroke (IS) susceptibility. However, the conclusions of case-control studies that evaluated the relationship between MMP-9rs3918242 variants and the risk of IS were still equivocal. Herein, we conducted a comprehensive meta-analysis to investigate the association between MMP-9rs3918242 variants and the risk of IS. METHODS: We searched 5 databases (PubMed, EMBASE, Google Scholar, Web of Science, and Chinese Biomedical Literature Database) to identify the eligible studies up to October of 2016. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association of MMP-9rs3918242 variants with IS susceptibility under the allelic model (T versus C) and the dominant model (TT + CT versus CC). RESULTS: A total of 14 studies with 3233 cases and 3123 controls were included in this meta-analysis. Our meta-analysis indicated that MMP-9rs3918242 variants were associated with significantly increased risk of IS in overall populations (T versus C: OR = 1.43, 95% CI = 1.20-1.71, P < .001; TT + CT versus CC: OR = 1.39, 95% CI = 1.16-1.67, P < .001). Subgroup analysis based on ethnicity (Chinese and Caucasian) suggested that MMP-9rs3918242 variants contributed to increase the risk of IS in Chinese population; However, no association was detected between MMP-9rs3918242 variants and the risk of IS in Caucasian population. CONCLUSION: Therefore, our meta-analysis suggested that MMP-9rs3918242 variants (T allele, TT and CT genotypes) contributed to significantly increase the risk of IS in the Chinese population.
Authors: Khalid Khalaf Alharbi; Imran Ali Khan; Mohammad Abdullah Alotaibi; Abdullah Saud Aloyaid; Haifa Abdulaziz Al-Basheer; Naelah Abdullah Alghamdi; Raid Saleem Al-Baradie; A M Al-Sulaiman Journal: Saudi J Biol Sci Date: 2017-08-24 Impact factor: 4.219