Literature DB >> 28258570

Aquaporins in Digestive System.

Shuai Zhu1, Jianhua Ran2, Baoxue Yang1,3,4, Zhechuan Mei5.   

Abstract

In this chapter, we mainly discuss the expression and function of aquaporins (AQPs ) expressed in digestive system . AQPs in gastrointestinal tract include four members of aquaporin subfamily: AQP1, AQP4, AQP5 and AQP8, and a member of aquaglyceroporin subfamily: AQP3. In the digestive glands, especially the liver, we discuss three members of aquaporin subfamily: AQP1, AQP5 and AQP8, a member of aquaglyceroporin subfamily: AQP9. AQP3 is involved in the diarrhea and inflammatory bowel disease; AQP5 is relevant to gastric carcinoma cell proliferation and migration; AQP9 plays considerable role in glycerol metabolism , urea transport and hepatocellular carcinoma. Further investigation is necessary for specific locations and functions of AQPs in digestive system.

Entities:  

Keywords:  Aquaporins; Diabetes; Digestive system; Gastrointestinal tract; Glycerol metabolism; Water electrolyte balance

Mesh：

Substances：

Year:  2017        PMID： 28258570     DOI： 10.1007/978-94-024-1057-0_8

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  7 in total

1.  Interferon gamma decreases intestinal epithelial aquaporin 3 expression through downregulation of constitutive transcription.

Authors:  Michael A Peplowski; Michael Dicay; Cristiane H Baggio; Filip Wysokinski; Bernard Renaux; Morley D Hollenberg; David Proud; Wallace K MacNaughton
Journal:  J Mol Med (Berl)       Date:  2018-08-08       Impact factor: 4.599

2.  MiR-185-3p mimic promotes the chemosensitivity of CRC cells via AQP5.

Authors:  Chunhua Zhou; Wencheng Kong; Tongfa Ju; Qi Xie; Lulu Zhai
Journal:  Cancer Biol Ther       Date:  2020-06-26       Impact factor: 4.742

3.  Helicobacter pylori infection activates Wnt/β-catenin pathway to promote the occurrence of gastritis by upregulating ASCL1 and AQP5.

Authors:  Wei Zuo; Hui Yang; Nianshuang Li; Yaobin Ouyang; Xinbo Xu; Junbo Hong
Journal:  Cell Death Discov       Date:  2022-05-10

4.  AQP1 Is Up-Regulated by Hypoxia and Leads to Increased Cell Water Permeability, Motility, and Migration in Neuroblastoma.

Authors:  Zihe Huo; Mihai Lomora; Urs Kym; Cornelia Palivan; Stefan G Holland-Cunz; Stephanie J Gros
Journal:  Front Cell Dev Biol       Date:  2021-02-11

5.  Network pharmacological prediction and molecular docking analysis of the combination of Atractylodes macrocephala Koidz. and Paeonia lactiflora Pall. in the treatment of functional constipation and its verification.

Authors:  Yuxiao Meng; Xiaojun Li; Xiaoting Wang; Lu Zhang; Jiaqi Guan
Journal:  Animal Model Exp Med       Date:  2022-04-22

6.  Prevention of Loperamide-Induced Constipation in Mice and Alteration of 5-Hydroxytryotamine Signaling by Ligilactobacillus salivarius Li01.

Authors:  Bo Qiu; Lian Zhu; Shuobo Zhang; Shengyi Han; Yiqiu Fei; Furong Ba; Björn Berglund; Lanjuan Li; Mingfei Yao
Journal:  Nutrients       Date:  2022-10-01       Impact factor: 6.706

7.  MiR-877 suppresses gastric cancer progression by downregulating AQP3.

Authors:  Hongyu Zhu; Yulian Wu; Muxing Kang; Bo Zhang
Journal:  J Int Med Res       Date:  2020-06       Impact factor: 1.671
  7 in total

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