Jacqueline R Center1. 1. Bone Biology Division, Garvan Institute of Medical Research, St Vincent's Hospital Clinical School, School of Medicine, University of New South Wales, 384 Victoria St, Darlinghurst, NSW, 2010, Australia. j.center@garvan.org.au.
Abstract
PURPOSE OF THE REVIEW: This review aims to highlight important clinical findings from the over 25 year-long Dubbo Osteoporosis Epidemiology Study particularly focusing on outcomes post fracture. RECENT FINDINGS: Every low trauma fracture in the elderly is associated with an increased risk of a subsequent fracture, with a higher risk in men than women. All major or proximal fractures and even minor fractures in the very elderly or minor fractures that are then followed by re-fracture are associated with premature mortality, greatest in the first 5 years post fracture. Having a subsequent fracture further increases this high mortality risk, but if an individual survives the high risk period, their risk returns to that of the background population. Non-hip non-vertebral fractures account for a significant proportion of the premature mortality. Despite an improvement in overall health and population mortality over the years, excess mortality post fracture has not changed in the last 2 decades. All low trauma, fractures in the elderly herald a high risk of poor outcomes, particularly in the first few years post fracture. Early intervention should be initiated.
PURPOSE OF THE REVIEW: This review aims to highlight important clinical findings from the over 25 year-long Dubbo Osteoporosis Epidemiology Study particularly focusing on outcomes post fracture. RECENT FINDINGS: Every low trauma fracture in the elderly is associated with an increased risk of a subsequent fracture, with a higher risk in men than women. All major or proximal fractures and even minor fractures in the very elderly or minor fractures that are then followed by re-fracture are associated with premature mortality, greatest in the first 5 years post fracture. Having a subsequent fracture further increases this high mortality risk, but if an individual survives the high risk period, their risk returns to that of the background population. Non-hip non-vertebral fractures account for a significant proportion of the premature mortality. Despite an improvement in overall health and population mortality over the years, excess mortality post fracture has not changed in the last 2 decades. All low trauma, fractures in the elderly herald a high risk of poor outcomes, particularly in the first few years post fracture. Early intervention should be initiated.
Authors: Ming Li Yee; Raphael Hau; Alison Taylor; Mark Guerra; Peter Guerra; Peteris Darzins; Christopher Gilfillan Journal: Osteoporos Sarcopenia Date: 2020-07-18
Authors: Lei Si; John A Eisman; Tania Winzenberg; Kerrie M Sanders; Jacqueline R Center; Tuan V Nguyen; Andrew J Palmer Journal: BMJ Open Date: 2019-02-18 Impact factor: 2.692
Authors: Li-Wen Huang; Dong Sun; Thomas M Link; Thomas Lang; Weiyun Ai; Lawrence D Kaplan; Michael A Steinman; Charalambos Andreadis Journal: Support Care Cancer Date: 2021-03-10 Impact factor: 3.603