| Literature DB >> 28258171 |
Payam Shahi1, Chih-Yang Wang1, Devon A Lawson1, Euan M Slorach1, Angela Lu1, Ying Yu1, Ming-Derg Lai2, Hugo Gonzalez Velozo1, Zena Werb3.
Abstract
The transcription factor GATA3 is the master regulator that drives mammary luminal epithelial cell differentiation and maintains mammary gland homeostasis. Loss of GATA3 is associated with aggressive breast cancer development. We have identified ZNF503/ZEPPO2 zinc-finger elbow-related proline domain protein 2 (ZPO2) as a transcriptional repressor of GATA3 expression and transcriptional activity that induces mammary epithelial cell proliferation and breast cancer development. We show that ZPO2 is recruited to GATA3 promoter in association with ZBTB32 (Repressor of GATA, ROG) and that ZBTB32 is essential for down-regulation of GATA3 via ZPO2. Through this modulation of GATA3 activity, ZPO2 promotes aggressive breast cancer development. Our data provide insight into a mechanism of GATA3 regulation, and identify ZPO2 as a possible candidate gene for future diagnostic and therapeutic strategies.Entities:
Keywords: GATA3; ZBTB32; ZNF503/ZPO2; breast cancer; tumor metastasis
Mesh：
Substances：
Year: 2017 PMID： 28258171 PMCID： PMC5373372 DOI： 10.1073/pnas.1701690114
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205