Literature DB >> 28256838

Genome Mining of Streptomyces mobaraensis DSM40847 as a Bleomycin Producer Providing a Biotechnology Platform To Engineer Designer Bleomycin Analogues.

Dong Yang1, Qihui Teng1, Liao-Bin Dong1, Ivana Crnovčić1, Tingting Huang1, Huiming Ge1, Ben Shen1.   

Abstract

Streptomyces mobaraensis DSM40847 has been identified by genome mining and confirmed to be a new bleomycin (BLM) producer. Manipulation of BLM biosynthesis in S. mobaraensis has been demonstrated, as exemplified by the engineered production of 6'-deoxy-BLM A2, providing a biotechnology platform for BLM biosynthesis and engineering. Comparison of DNA cleavage efficiency and kinetics among 6'-deoxy-BLM A2 and selected analogues supports the wisdom of altering the disaccharide moiety to fine-tune BLM activity.

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Year:  2017        PMID： 28256838     DOI： 10.1021/acs.orglett.7b00283

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

1.  Discovery of the Tiancilactone Antibiotics by Genome Mining of Atypical Bacterial Type II Diterpene Synthases.

Authors:  Liao-Bin Dong; Jeffrey D Rudolf; Ming-Rong Deng; Xiaohui Yan; Ben Shen
Journal:  Chembiochem       Date:  2018-05-27       Impact factor: 3.164

2.  Engineered production and evaluation of 6'-deoxy-tallysomycin H-1 revealing new insights into the structure-activity relationship of the anticancer drug bleomycin.

Authors:  Dong Yang; Liao-Bin Dong; Ivana Crnovcic; Ben Shen
Journal:  J Antibiot (Tokyo)       Date:  2017-08-23       Impact factor: 2.649

3.  Submerged fermentation of Streptomyces uncialis providing a biotechnology platform for uncialamycin biosynthesis, engineering, and production.

Authors:  Dong Yang; Jun Luo; Tingting Huang; Xiaohui Yan; Ajeeth Adhikari; Christiana N Teijaro; Huiming Ge; Ben Shen
Journal:  J Ind Microbiol Biotechnol       Date:  2021-06-04       Impact factor: 4.258

Review 4.  Streptomyces as a Prominent Resource of Future Anti-MRSA Drugs.

Authors:  Hefa Mangzira Kemung; Loh Teng-Hern Tan; Tahir Mehmood Khan; Kok-Gan Chan; Priyia Pusparajah; Bey-Hing Goh; Learn-Han Lee
Journal:  Front Microbiol       Date:  2018-09-24       Impact factor: 5.640

5.  Enhancement of bleomycin production in Streptomyces verticillus through global metabolic regulation of N-acetylglucosamine and assisted metabolic profiling analysis.

Authors:  Hong Chen; Jiaqi Cui; Pan Wang; Xin Wang; Jianping Wen
Journal:  Microb Cell Fact       Date:  2020-02-13       Impact factor: 5.328

6.  Desert Environments Facilitate Unique Evolution of Biosynthetic Potential in Streptomyces.

Authors:  Kunjukrishnan Kamalakshi Sivakala; Karina Gutiérrez-García; Polpass Arul Jose; Thangadurai Thinesh; Rangasamy Anandham; Francisco Barona-Gómez; Natesan Sivakumar
Journal:  Molecules       Date:  2021-01-22       Impact factor: 4.411

Review 7.  Natural products in drug discovery: advances and opportunities.

Authors:  Atanas G Atanasov; Sergey B Zotchev; Verena M Dirsch; Claudiu T Supuran
Journal:  Nat Rev Drug Discov       Date:  2021-01-28       Impact factor: 112.288
  7 in total

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