| Literature DB >> 28255881 |
Neeraj Kohli1, Melissa L Geddie2.
Abstract
The discovery of antibodies that bind to targets with high affinity is now a routine exercise. However, it is still challenging to screen for candidates that, in addition to having excellent biological properties, also have optimal biophysical characteristics. Here, we describe a simple HPLC-based screening method to assess for developability factors earlier in the discovery process.Keywords: Colloidal stability; Developability; Size exclusion chromatography; Standup monolayer adsorption chromatography; Zenix column
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Year: 2017 PMID： 28255881 DOI： 10.1007/978-1-4939-6857-2_11
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745