Håvard Nygaard1, Gunnar Slettaløkken Falch2, Jon Elling Whist3,4, Ivana Hollan5,4,6,7, Stian Ellefsen2, Gerd Holmboe-Ottesen8, Bent R Rønnestad2, Arne T Høstmark8. 1. Section for Sport Science, Lillehammer University College, PB 952, 2604, Lillehammer, Norway. havard.nygaard@inn.no. 2. Section for Sport Science, Lillehammer University College, PB 952, 2604, Lillehammer, Norway. 3. Department of Medical Biochemistry, Innlandet Hospital Trust, PB 990, 2629, Lillehammer, Norway. 4. Department of Research, Innlandet Hospital Trust, Brumunddal, Norway. 5. Hospital for Rheumatic Diseases, Margrethe Grundtvigs veg 6, 2609, Lillehammer, Norway. 6. Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA. 7. Harvard Medical School, Boston, MA, USA. 8. Department of Community Medicine, Institute of Health and Society, University of Oslo, PB 1130 Blindern, 0318, Oslo, Norway.
Abstract
PURPOSE: Systemic inflammation is involved in the development of several diseases, including cardiovascular disease and type 2 diabetes. It is known that vigorous exercise affects systemic inflammation, but less is known about exercise at lower intensities. Hyperglycemia can also entail pro-inflammatory responses; however, postprandial hyperglycemia is blunted if the meal is followed by exercise. Hypotheses were: (1) moderate physical exercise acutely affects levels of C-reactive protein (CRP) and serum soluble vascular cell adhesion molecule 1 (sVCAM-1) in hyperglycemic individuals and (2) the effect depends on whether the activity is performed in a post-absorptive or postprandial state. METHODS:Twelve participants diagnosed with hyperglycemia, but not using anti-diabetic medication, underwent three test days in a randomized cross-over study; 1 control day without exercise, 1 day with 60 min of treadmill walking ending 30 min before breakfast, and 1 day with an identical bout of activity 30 min after the start of breakfast. Food intake was strictly standardized and venous blood for CRP, and sVCAM-1 analysis was sampled at standardized timepoints during the first 3.5 h after breakfast and once 24 h later. RESULTS: Merged data from the two exercise days showed that sVCAM-1 increased from baseline (4 ± 16 ng/mL) compared to the control condition (-28 ± 47 ng/mL, ES = 0.7, p = 0.024). There was no statistically significant difference in changes in sVCAM-1 levels between the two exercise test days. Exercise did not affect CRP values. CONCLUSION:Moderate exercise increases sVCAM-1 in hyperglycemic individuals, whereas it does not affect CRP.
RCT Entities:
PURPOSE: Systemic inflammation is involved in the development of several diseases, including cardiovascular disease and type 2 diabetes. It is known that vigorous exercise affects systemic inflammation, but less is known about exercise at lower intensities. Hyperglycemia can also entail pro-inflammatory responses; however, postprandial hyperglycemia is blunted if the meal is followed by exercise. Hypotheses were: (1) moderate physical exercise acutely affects levels of C-reactive protein (CRP) and serum soluble vascular cell adhesion molecule 1 (sVCAM-1) in hyperglycemic individuals and (2) the effect depends on whether the activity is performed in a post-absorptive or postprandial state. METHODS: Twelve participants diagnosed with hyperglycemia, but not using anti-diabetic medication, underwent three test days in a randomized cross-over study; 1 control day without exercise, 1 day with 60 min of treadmill walking ending 30 min before breakfast, and 1 day with an identical bout of activity 30 min after the start of breakfast. Food intake was strictly standardized and venous blood for CRP, and sVCAM-1 analysis was sampled at standardized timepoints during the first 3.5 h after breakfast and once 24 h later. RESULTS: Merged data from the two exercise days showed that sVCAM-1 increased from baseline (4 ± 16 ng/mL) compared to the control condition (-28 ± 47 ng/mL, ES = 0.7, p = 0.024). There was no statistically significant difference in changes in sVCAM-1 levels between the two exercise test days. Exercise did not affect CRP values. CONCLUSION: Moderate exercise increases sVCAM-1 in hyperglycemic individuals, whereas it does not affect CRP.
Entities:
Keywords:
Atherosclerosis; Blood; CRP; Life style; Physical activity; sVCAM-1
Authors: Francesco Nappo; Katherine Esposito; Michele Cioffi; Giovanni Giugliano; Anna Maria Molinari; Giuseppe Paolisso; Raffaele Marfella; Dario Giugliano Journal: J Am Coll Cardiol Date: 2002-04-03 Impact factor: 24.094
Authors: Jan K Nowak; Irena Wojsyk-Banaszak; Edyta Mądry; Andrzej Wykrętowicz; Patrycja Krzyżanowska; Sławomira Drzymała-Czyż; Agata Nowicka; Andrzej Pogorzelski; Ewa Sapiejka; Wojciech Skorupa; Mariusz Szczepanik; Aleksandra Lisowska; Jaroslaw Walkowiak Journal: Lung Date: 2017-06-23 Impact factor: 2.584