Literature DB >> 28254527

Osteopontin splice variants and polymorphisms in cancer progression and prognosis.

Marco Antonio Briones-Orta1, S Eréndira Avendaño-Vázquez2, Diana Ivette Aparicio-Bautista3, Jason D Coombes1, Georg F Weber4, Wing-Kin Syn5.   

Abstract

Osteopontin (OPN) is an extracellular matrix protein that is overexpressed in various cancers and promotes oncogenic features including cell proliferation, survival, migration, and angiogenesis, among others. OPN can participate in the regulation of the tumor microenvironment, affecting both cancer and neighboring cells. Here, we review the roles of OPN splice variants (a, b, c) in cancer development, progression, and prognosis, and also discuss the identities of isoforms 4 and 5. We also discussed how single-nucleotide polymorphisms (SNPs) of the OPN gene are an additional factor influencing the level of OPN in individuals, modulating the risks of cancer development and outcome. Published by Elsevier B.V.

Entities:  

Keywords:  Alternative splicing isoforms; Malignancy; Prognosis; Single nucleotide polymorphisms (SNPs); Spp1

Mesh：

Substances：

Year:  2017        PMID： 28254527     DOI： 10.1016/j.bbcan.2017.02.005

Source DB:  PubMed          Journal:  Biochim Biophys Acta Rev Cancer        ISSN： 0304-419X            Impact factor:   10.680


  25 in total

1.  Prostatic osteopontin expression is associated with symptomatic benign prostatic hyperplasia.

Authors:  Petra Popovics; Wisam N Awadallah; Sarah E Kohrt; Thomas C Case; Nicole L Miller; Emily A Ricke; Wei Huang; Marisol Ramirez-Solano; Qi Liu; Chad M Vezina; Robert J Matusik; William A Ricke; Magdalena M Grabowska
Journal:  Prostate       Date:  2020-05-01       Impact factor: 4.104

2.  Osteopontin in Vascular Disease.

Authors:  Zoe Shin Yee Lok; Alicia N Lyle
Journal:  Arterioscler Thromb Vasc Biol       Date:  2019-04       Impact factor: 8.311

Review 3.  Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics.

Authors:  Laura M Urbanski; Nathan Leclair; Olga Anczuków
Journal:  Wiley Interdiscip Rev RNA       Date:  2018-04-25       Impact factor: 9.957

Review 4.  The Roles of Matricellular Proteins in Oncogenic Virus-Induced Cancers and Their Potential Utilities as Therapeutic Targets.

Authors:  Naoyoshi Maeda; Katsumi Maenaka
Journal:  Int J Mol Sci       Date:  2017-10-21       Impact factor: 5.923

5.  Prognostic value of OCT4A and SPP1C transcript variant co-expression in early-stage lung adenocarcinoma.

Authors:  Seijiro Koshimune; Mitsuko Kosaka; Nobuhiko Mizuno; Hiromasa Yamamoto; Tomoyuki Miyamoto; Kohta Ebisui; Shinichi Toyooka; Aiji Ohtsuka
Journal:  BMC Cancer       Date:  2020-06-05       Impact factor: 4.430

6.  Promotion of rs3746804 (p. L267P) polymorphism to intracellular SLC52A3a trafficking and riboflavin transportation in esophageal cancer cells.

Authors:  Lin Long; Xiao-Xiao Pang; Fa-Min Zeng; Xiu-Hui Zhan; Ying-Hua Xie; Feng Pan; Wei Wang; Lian-Di Liao; Xiu-E Xu; Bin Li; Li-Dong Wang; Zhi-Jie Chang; En-Min Li; Li-Yan Xu
Journal:  Amino Acids       Date:  2021-07-05       Impact factor: 3.520

7.  Prediction of transcription factor bindings sites affected by SNPs located at the osteopontin promoter.

Authors:  Marco Antonio Briones-Orta; S Eréndira Avendaño-Vázquez; Diana Ivette Aparicio-Bautista; Jason D Coombes; Georg F Weber; Wing-Kin Syn
Journal:  Data Brief       Date:  2017-08-02

Review 8.  Osteopontin at the Crossroads of Inflammation and Tumor Progression.

Authors:  Luigi Mario Castello; Davide Raineri; Livia Salmi; Nausicaa Clemente; Rosanna Vaschetto; Marco Quaglia; Massimiliano Garzaro; Sergio Gentilli; Paolo Navalesi; Vincenzo Cantaluppi; Umberto Dianzani; Anna Aspesi; Annalisa Chiocchetti
Journal:  Mediators Inflamm       Date:  2017-07-09       Impact factor: 4.711

9.  Synthesis of a Cleaved Form of Osteopontin by THP-1 Cells and Its Alteration by Phorbol 12-Myristate 13-Acetate and BCG Infection.

Authors:  Gaowa Bai; Hirotoshi Motoda; Ryo Ozuru; Haorile Chagan-Yasutan; Toshio Hattori; Takashi Matsuba
Journal:  Int J Mol Sci       Date:  2018-01-31       Impact factor: 5.923

10.  A robust twelve-gene signature for prognosis prediction of hepatocellular carcinoma.

Authors:  Guoqing Ouyang; Bin Yi; Guangdong Pan; Xiang Chen
Journal:  Cancer Cell Int       Date:  2020-06-03       Impact factor: 5.722
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