| Literature DB >> 28254431 |
Wenhui Zhao1, Jing Yan1, Liyun Gao2, Jinfeng Zhao3, Conglin Zhao4, Chao Gao4, Xiaoqiu Luo4, Xinshu Zhu5.
Abstract
Transforming Growth Factor β1 (TGF-β1), a well-known neuroprotective and neurotrophic factor in the central nervous system, is also involved in the repair process responses after ischemia-reperfusion injury. Herein, we found that TGF-β1 enhanced Cdk5 expression while decreased Tunel-positive cells compared with the ischemia group, and roscovitine(Cdk5 inhibitor) treatment could blunt these effects. In vitro study, TGF-β1 facilitated Cdk5/p35 complex, the proliferation, neurite growth and differentiation of PC12 cells, effects of which could be blunted by roscovitine and Cdk5 silencing. Moreover, ERK1/2 inhibitor SCH772984 abrogated the effects of TGF- β1 on Cdk5 and Bax levels. Taken together, we conclude that Cdk5 contributes to the neuroprotective function of TGF- β1 via ERK1/2 signaling.Entities:
Keywords: Cdk5; Ischemia-reperfusion; PC12 cells; Roscovitine; TGF-β
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Year: 2017 PMID： 28254431 DOI： 10.1016/j.bbrc.2017.02.130
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575