| Literature DB >> 28254409 |
Guangbing Xiong1, Mengyu Feng2, Gang Yang3, Suli Zheng4, Xujun Song5, Zhe Cao6, Lei You7, Lianfang Zheng8, Ya Hu9, Taiping Zhang10, Yupei Zhao11.
Abstract
Pancreatic cancer, which is often asymptomatic, is currently one of the most common causes of cancer-related death. This phenomenon is most likely due to a lack of early diagnosis, a high metastasis rate and a disappointing chemotherapy outcome. Thus, improving treatment outcomes by overcoming chemotherapy resistance may be a useful strategy in pancreatic cancer. Various underlying mechanisms involved in the chemoresistance of pancreatic cancer have been investigated. Notably, non-coding RNAs (ncRNAs), especially microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), play a pivotal role in regulating sensitivity to chemotherapy in pancreatic cancer. In this review, we highlight recent evidence regarding the role of miRNAs and lncRNAs in the chemoresistance of pancreatic cancer, including their expression levels, targets, biological functions and the regulation of chemoresistance, and discuss the potential clinical application of miRNAs and lncRNAs in the treatment of pancreatic cancer.Entities:
Keywords: Chemoresistance; Long non-coding RNA; Mechanism; Pancreatic cancer; microRNA
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Year: 2017 PMID： 28254409 DOI： 10.1016/j.canlet.2017.02.020
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679