Literature DB >> 2825402

Mediastinal large-cell lymphoma with sclerosis. Genotypic analysis establishes its B nature.

A Scarpa1, F Bonetti, F Menestrina, M Menegazzi, M Chilosi, M Lestani, C Bovolenta, G Zamboni, L Fiore-Donati.   

Abstract

The Southern blot hybridization technique has been applied to study the configuration of immunoglobulin and T-cell receptor genes in 6 cases of the so called mediastinal large cell lymphoma with sclerosis. This lymphoma has been recently recognized as a separate entity among non-Hodgkin lymphomas mainly affecting young adult patients. The B-cell origin of this neoplasm was suggested by means of immunohistochemical analysis. However, the immunophenotypical B-cell related markers used do not always exhibit lineage fidelity. The Southern blot analysis demonstrated the presence of unique heavy and k-light chain immunoglobulin gene rearrangements, establishing genotypically their B-cell origin.

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Year:  1987        PMID： 2825402     DOI： 10.1007/BF00750725

Source DB:  PubMed          Journal:  Virchows Arch A Pathol Anat Histopathol        ISSN： 0174-7398


  22 in total

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Journal:  J Mol Biol       Date:  1977-06-15       Impact factor: 5.469

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Authors:  P Möller; B Lämmler; M Eberlein-Gonska; G E Feichter; W J Hofmann; H Schmitteckert; H F Otto
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1986

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Journal:  J Clin Pathol       Date:  1987-02       Impact factor: 3.411

4.  Mediastinal large-cell lymphoma of B-type, with sclerosis: histopathological and immunohistochemical study of eight cases.

Authors:  F Menestrina; M Chilosi; F Bonetti; M Lestani; A Scarpa; P Novelli; C Doglioni; G Todeschini; A Ambrosetti; L Fiore-Donati
Journal:  Histopathology       Date:  1986-06       Impact factor: 5.087

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Journal:  Nature       Date:  1984 Dec 6-12       Impact factor: 49.962

6.  Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments.

Authors:  P A Hieter; E E Max; J G Seidman; J V Maizel; P Leder
Journal:  Cell       Date:  1980-11       Impact factor: 41.582

7.  Malignant histiocytosis of the intestine: a T-cell lymphoma.

Authors:  P G Isaacson; N T O'Connor; J Spencer; D H Bevan; C E Connolly; N Kirkham; D J Pollock; J S Wainscoat; H Stein; D Y Mason
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8.  Immunoglobulin-gene rearrangements as unique clonal markers in human lymphoid neoplasms.

Authors:  A Arnold; J Cossman; A Bakhshi; E S Jaffe; T A Waldmann; S J Korsmeyer
Journal:  N Engl J Med       Date:  1983-12-29       Impact factor: 91.245

9.  Primary mediastinal non-Hodgkin's lymphomas: a morphologic and immunologic study of 19 cases.

Authors:  S A Yousem; L M Weiss; R A Warnke
Journal:  Am J Clin Pathol       Date:  1985-06       Impact factor: 2.493

10.  Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins.

Authors:  S J Korsmeyer; A Arnold; A Bakhshi; J V Ravetch; U Siebenlist; P A Hieter; S O Sharrow; T W LeBien; J H Kersey; D G Poplack; P Leder; T A Waldmann
Journal:  J Clin Invest       Date:  1983-02       Impact factor: 14.808
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  7 in total

Review 1.  Tumours of the thymus and their nomenclature.

Authors:  H F Otto
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1991

2.  [Mediastinal large B-cell lymphoma].

Authors:  T F E Barth; P Möller
Journal:  Pathologe       Date:  2007-02       Impact factor: 1.011

3.  Adhesion receptor profile of thymic B-cell lymphoma.

Authors:  A Eichelmann; K Koretz; G Mechtersheimer; P Möller
Journal:  Am J Pathol       Date:  1992-09       Impact factor: 4.307

4.  Discordant expression of immunoglobulin and its associated molecule mb-1/CD79a is frequently found in mediastinal large B cell lymphomas.

Authors:  P Kanavaros; P Gaulard; F Charlotte; N Martin; C Ducos; M Lebezu; D Y Mason
Journal:  Am J Pathol       Date:  1995-03       Impact factor: 4.307

5.  Primary mediastinal B-cell lymphoma: high frequency of BCL-6 mutations and consistent expression of the transcription factors OCT-2, BOB.1, and PU.1 in the absence of immunoglobulins.

Authors:  Stefano A Pileri; Gianluca Gaidano; Pier Luigi Zinzani; Brunangelo Falini; Philippe Gaulard; Emanuele Zucca; Federica Pieri; Eva Berra; Elena Sabattini; Stefano Ascani; Milena Piccioli; Peter W M Johnson; Roberto Giardini; Edoardo Pescarmona; Domenico Novero; Pier Paolo Piccaluga; Teresa Marafioti; Miguel A Alonso; Franco Cavalli
Journal:  Am J Pathol       Date:  2003-01       Impact factor: 4.307

6.  Mediastinal large-cell lymphoma with sclerosis (MLCLS).

Authors:  A Z Rohatiner; J S Whelan; R K Ganjoo; A J Norton; A Wilson; T A Lister
Journal:  Br J Cancer       Date:  1994-03       Impact factor: 7.640

7.  Primary mediastinal large B-cell lymphoma (PMLBCL): long-term results from a retrospective multicentre Italian experience in 138 patients treated with CHOP or MACOP-B/VACOP-B.

Authors:  G Todeschini; S Secchi; E Morra; U Vitolo; E Orlandi; F Pasini; E Gallo; A Ambrosetti; C Tecchio; C Tarella; A Gabbas; A Gallamini; L Gargantini; M Pizzuti; G Fioritoni; L Gottin; G Rossi; M Lazzarino; F Menestrina; M Paulli; M Palestro; M G Cabras; F Di Vito; G Pizzolo
Journal:  Br J Cancer       Date:  2004-01-26       Impact factor: 7.640
  7 in total

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