| Literature DB >> 28253622 |
Alexander V Aksenov1, Dmitrii A Aksenov1, Naila A Orazova1, Nicolai A Aksenov1, Georgii D Griaznov1, Annelise De Carvalho2, Robert Kiss2, Véronique Mathieu2, Alexander Kornienko3, Michael Rubin1,4.
Abstract
Indolo[3,2-c]quinolones have been efficiently synthesized via an acid-mediated, one-pot, three-component condensation of arylhydrazines, o-aminoacetophenones, and triazines or nitriles. The synthetic application of this method is showcased by the concise synthesis of isocryptolepine alkaloid and a series of its synthetic analogues with demonstrated cancer cell antiproliferative activities.Entities:
Mesh：
Substances：
Year: 2017 PMID： 28253622 DOI： 10.1021/acs.joc.6b03084
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354