Galia Sheinberg1, Camilo Romero2, Rafael Heredia2, Miguel Capulin2, Enrique Yarto1, Juan Carpio3. 1. Centro Veterinario México, Calle Cincinnati #22, Benito Juárez, Cd de los Deportes, 03710, Ciudad de México, México. 2. Centro Universitario UAEM Amecameca, Universidad Autónoma del Estado de México, Km. 2.5 Carretera Amecameca-Ayapango, 56900, Amecameca de Juárez, Estado de México, México. 3. Departamento de Parasitología, Instituto de Diagnóstico y Referencia Epidemiológicos, Francisco de P. Miranda #177, Col. Unidad Lomas de Plateros Delegación, Alvaro Obregón, Ciudad de México, CP. 01480, México.
Abstract
BACKGROUND: Psoroptes cuniculi, a nonburrowing ear mite, is a common ectoparasite of rabbits. Constant irritation of the auditory canal by the presence of this mite can lead to otitis externa or otoacariasis. OBJECTIVE: The goal of this study was to evaluate the effect of fluralaner on rabbits naturally infested with P. cuniculi and exhibiting clinical signs. ANIMALS: Fifteen female New Zealand domestic rabbits with otitis due to naturally occurring infestation with P. cuniculi. METHODS: The external ears and ear canals of each individual were examined; samples of otic exudate were extracted with cotton swabs and examined microscopically for identification of the ectoparasite. Each animal was treated with a single 25 mg/kg oral dose of fluralaner. The amount of otic exudate/cerumen was assessed and samples were obtained from the ears to evaluate for presence or absence of mites at 4, 8, 12, 16, 20, 40 and 90 days after receiving treatment. RESULTS: Post-treatment, the amount of otic exudate decreased rapidly in all animals; by Day 12 and until the end of the study all rabbits were judged to have low amount of exudate with normally visible canals. The percentage of ears positive for P. cuniculi decreased to 13.3% of ears sampled by Day 4, and by Day 12 all rabbits were negative for the parasite. CONCLUSION: Administration of a single oral dose of fluralaner was effective for the treatment of naturally occurring P. cuniculi infestation in rabbits during a 90 day period.
BACKGROUND:Psoroptes cuniculi, a nonburrowing ear mite, is a common ectoparasite of rabbits. Constant irritation of the auditory canal by the presence of this mite can lead to otitis externa or otoacariasis. OBJECTIVE: The goal of this study was to evaluate the effect of fluralaner on rabbits naturally infested with P. cuniculi and exhibiting clinical signs. ANIMALS: Fifteen female New Zealand domestic rabbits with otitis due to naturally occurring infestation with P. cuniculi. METHODS: The external ears and ear canals of each individual were examined; samples of otic exudate were extracted with cotton swabs and examined microscopically for identification of the ectoparasite. Each animal was treated with a single 25 mg/kg oral dose of fluralaner. The amount of otic exudate/cerumen was assessed and samples were obtained from the ears to evaluate for presence or absence of mites at 4, 8, 12, 16, 20, 40 and 90 days after receiving treatment. RESULTS: Post-treatment, the amount of otic exudate decreased rapidly in all animals; by Day 12 and until the end of the study all rabbits were judged to have low amount of exudate with normally visible canals. The percentage of ears positive for P. cuniculi decreased to 13.3% of ears sampled by Day 4, and by Day 12 all rabbits were negative for the parasite. CONCLUSION: Administration of a single oral dose of fluralaner was effective for the treatment of naturally occurring P. cuniculi infestation in rabbits during a 90 day period.
Authors: Camilo Romero Núñez; Ariadna Flores Ortega; Galia Sheinberg Waisburd; Alberto Martin Cordero; Enrique Yarto Jaramillo; Rafael Heredia Cárdenas; Linda G Bautista Gómez Journal: PLoS One Date: 2020-03-27 Impact factor: 3.240