Literature DB >> 2825148

Xenografted small cell undifferentiated cancer of prostate: possible common origin with prostatic adenocarcinoma.

C van Haaften-Day1, D Raghavan, P Russell, E J Wills, P Gregory, W Tilley, D J Horsfall.   

Abstract

The first xenograft line of small cell undifferentiated carcinoma of the prostate (UCRU-PR-2) has been established and characterized. The donor tumor and the xenograft share the common morphological and ultrastructural features of small cell undifferentiated carcinoma (including neurosecretory granules) but also elaborate epithelial membrane antigen and carcinoembryonic antigen, in addition to neurone-specific enolase. The line expresses a diploid DNA complement. Androgen and estrogen receptors are not expressed, although prostatic acid phosphatase is present in sera from tumor-bearing mice in low levels. From these studies, we postulate a possible common stem cell origin for adenocarcinoma and small cell undifferentiated carcinoma of the prostate; further studies of a cell line derived from this tumor may clarify the issue.

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Year:  1987        PMID： 2825148     DOI： 10.1002/pros.2990110307

Source DB:  PubMed          Journal:  Prostate        ISSN： 0270-4137            Impact factor:   4.104


  13 in total

1.  Detection of tumor-associated membrane proteins in prostate and bladder carcinomas by means of protein blotting.

Authors:  S A Ford; P J Russell; M Jelbart; D Raghavan
Journal:  Urol Res       Date:  1989

2.  Case report: subcutaneous metastasis from small cell carcinoma of the prostate.

Authors:  Mustafa Kaplan; Irfan H Atakan; Selcuk Bilgi; Osman Inci
Journal:  Int Urol Nephrol       Date:  2007       Impact factor: 2.370

3.  Development and characterization of a human cell line from an ovarian mixed Müllerian tumor (carcinosarcoma).

Authors:  C van Haaften-Day; P Russell; S Carr; L Wright
Journal:  In Vitro Cell Dev Biol       Date:  1988-10

Review 4.  Human prostate cancer heterotransplants: a review on this experimental model.

Authors:  Lluis A Lopez-Barcons
Journal:  Asian J Androl       Date:  2010-04-05       Impact factor: 3.285

Review 5.  Small-cell neuroendocrine carcinoma of the prostate: are heterotransplants a better experimental model?

Authors:  Lluis-A Lopez-Barcons
Journal:  Asian J Androl       Date:  2009-12-21       Impact factor: 3.285

6.  Neuroendocrine prostate cancer xenografts with large-cell and small-cell features derived from a single patient's tumor: morphological, immunohistochemical, and gene expression profiles.

Authors:  Nora M Navone; Sankar N Maity; Ana Aparicio; Vasiliki Tzelepi; John C Araujo; Charles C Guo; Shoudan Liang; Patricia Troncoso; Christopher J Logothetis
Journal:  Prostate       Date:  2010-11-17       Impact factor: 4.104

7.  Biology and evolution of poorly differentiated neuroendocrine tumors.

Authors:  David S Rickman; Himisha Beltran; Francesca Demichelis; Mark A Rubin
Journal:  Nat Med       Date:  2017-06-06       Impact factor: 53.440

8.  A neuroendocrine/small cell prostate carcinoma xenograft-LuCaP 49.

Authors:  Lawrence D True; Kent Buhler; Janna Quinn; Emily Williams; Peter S Nelson; Nigel Clegg; Jill A Macoska; Thomas Norwood; Alvin Liu; William Ellis; Paul Lange; Robert Vessella
Journal:  Am J Pathol       Date:  2002-08       Impact factor: 4.307

9.  Do neuroendocrine cells in human prostate cancer express androgen receptor?

Authors:  J L Krijnen; P J Janssen; J A Ruizeveld de Winter; H van Krimpen; F H Schröder; T H van der Kwast
Journal:  Histochemistry       Date:  1993-11

10.  Neuroendocrine differentiation in human prostatic tumor models.

Authors:  M A Noordzij; W M van Weerden; C M de Ridder; T H van der Kwast; F H Schröder; G J van Steenbrugge
Journal:  Am J Pathol       Date:  1996-09       Impact factor: 4.307
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