Literature DB >> 28251033

Impaired inactivation of digestive proteases: The possible key factor for the high susceptibility of germ-free and antibiotic-treated animals to gut epithelial injury.

Xiaofa Qin1.   

Abstract

Recent study shows that germ-free and antibiotic-treated animals are highly susceptible to gut epithelial injury. This paper addresses that impaired inactivation of digestive proteases may be the key factor for the increased susceptibility.

Entities:  

Keywords:  Antibiotics; Digestive proteases; Germ-free; Gut epithelial injury; Gut microbiota

Year:  2017        PMID： 28251033      PMCID： PMC5311466          DOI： 10.4291/wjgp.v8.i1.1

Source DB:  PubMed          Journal:  World J Gastrointest Pathophysiol        ISSN： 2150-5330


  10 in total

1.  Influence of antibiotics on some intestinal microflora associated characteristics.

Authors:  K E Norin
Journal:  Anaerobe       Date:  1997 Apr-Jun       Impact factor: 3.331

2.  Metabolic changes in the intestinal mucosa during hemorrhagic shock.

Authors:  G Bounous
Journal:  Can J Surg       Date:  1965-10       Impact factor: 2.089

3.  Pancreatic enzymes in germfree and conventional rats fed chemically defined, water-soluble diet free from natural substrates.

Authors:  B S Reddy; J R Pleasants; B S Wostmann
Journal:  J Nutr       Date:  1969-03       Impact factor: 4.798

4.  Establishment of a biochemically active intestinal ecosystem in ex-germfree rats.

Authors:  T Midtvedt; B Carlstedt-Duke; T Höverstad; A C Midtvedt; K E Norin; H Saxerholt
Journal:  Appl Environ Microbiol       Date:  1987-12       Impact factor: 4.792

Review 5.  The physiological importance of the colonic microflora.

Authors:  B E Gustafsson
Journal:  Scand J Gastroenterol Suppl       Date:  1982

Review 6.  Etiology of inflammatory bowel disease: a unified hypothesis.

Authors:  Xiaofa Qin
Journal:  World J Gastroenterol       Date:  2012-04-21       Impact factor: 5.742

7.  Quantitation of active pancreatic endopeptidases in the intestinal contents of germfree and conventional rats.

Authors:  S Genell; B E Gustafsson; K Ohlsson
Journal:  Scand J Gastroenterol       Date:  1976       Impact factor: 2.423

8.  Impaired enteric degradation of pancreatic endopeptidases in antibiotic-treated rats.

Authors:  S Genell; B E Gustafsson
Journal:  Scand J Gastroenterol       Date:  1977       Impact factor: 2.423

9.  Impaired inactivation of digestive proteases by deconjugated bilirubin: the possible mechanism for inflammatory bowel disease.

Authors:  X F Qin
Journal:  Med Hypotheses       Date:  2002-08       Impact factor: 1.538

10.  Germ-free and Antibiotic-treated Mice are Highly Susceptible to Epithelial Injury in DSS Colitis.

Authors:  Cristina Hernández-Chirlaque; Carlos J Aranda; Borja Ocón; Fermín Capitán-Cañadas; Mercedes Ortega-González; Juan Jesús Carrero; María Dolores Suárez; Antonio Zarzuelo; Fermín Sánchez de Medina; Olga Martínez-Augustin
Journal:  J Crohns Colitis       Date:  2016-04-26       Impact factor: 9.071
  10 in total

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