Literature DB >> 28250422

Components of the folate metabolic pathway and ADHD core traits: an exploration in eastern Indian probands.

Tanusree Saha1, Mahasweta Chatterjee1, Swagata Sinha2, Usha Rajamma1, Kanchan Mukhopadhyay1.   

Abstract

We investigated role of the folate-homocysteine metabolic pathway in the etiology of attention-deficit hyperactivity disorder (ADHD) due to its importance in maintaining DNA integrity as well as neurotransmission. Functional gene variants in MTR (rs1805087), CBS (rs5742905), MTHFR (rs1801133 &rs1801131), MTHFD (rs2236225), RFC1 (rs1051266), plasma vitamin B12, folate and homocysteine were analyzed. rs1805087 'A' showed strong association with ADHD. Vitamin B12 deficiency of ADHD probands (P=0.01) correlated with rs1801133 'T' and rs1805087'GG'. Mild hyperhomocysteinemia (P=0.05) in the probands was associated with rs1805087 'AA'. Probands having rs1805087 'GG' and rs1051266 'G' was more inattentive. Hyperactivity-impulsivity score revealed association with rs5742905 'TT' and rs2236225 'CC', while rs1801133 'CC' showed association with inattentiveness and hyperactivity-impulsivity. rs1801131 exhibited strong synergistic interaction with rs1051266 and rs2236225. This indicated that the folate-homocysteine pathway gene variants may affect ADHD etiology through mild hyperhomocysteinemia and vitamin B12 deficiency, factors known to be associated with cognitive deficit.

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Year:  2017        PMID： 28250422     DOI： 10.1038/jhg.2017.23

Source DB:  PubMed          Journal:  J Hum Genet        ISSN： 1434-5161            Impact factor:   3.172


  69 in total

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Review 3.  Molecular genetics of attention-deficit/hyperactivity disorder.

Authors:  Stephen V Faraone; Roy H Perlis; Alysa E Doyle; Jordan W Smoller; Jennifer J Goralnick; Meredith A Holmgren; Pamela Sklar
Journal:  Biol Psychiatry       Date:  2005-01-21       Impact factor: 13.382

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Journal:  Eur J Pediatr       Date:  2006-10-11       Impact factor: 3.183

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Authors:  M Y Tsai; M Bignell; K Schwichtenberg; N Q Hanson
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7.  The molecular basis of homocystinuria due to cystathionine beta-synthase deficiency in Italian families, and report of four novel mutations.

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  5 in total

1.  A Common Polymorphism in the MTHFD1 Gene Is a Modulator of Risk of Congenital Heart Disease.

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Journal:  J Cardiovasc Dev Dis       Date:  2022-05-24

Review 2.  Methylenetetrahydrofolate reductase and psychiatric diseases.

Authors:  Lin Wan; Yuhong Li; Zhengrong Zhang; Zuoli Sun; Yi He; Rena Li
Journal:  Transl Psychiatry       Date:  2018-11-05       Impact factor: 6.222

Review 3.  Dissecting diagnostic heterogeneity in depression by integrating neuroimaging and genetics.

Authors:  Amanda M Buch; Conor Liston
Journal:  Neuropsychopharmacology       Date:  2020-08-11       Impact factor: 8.294

4.  Vitamin D Supplementation and Nordic Walking Training Decreases Serum Homocysteine and Ferritin in Elderly Women.

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Journal:  Int J Environ Res Public Health       Date:  2018-09-20       Impact factor: 3.390

5.  Comparison of serum B12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controls.

Authors:  Çiğdem Yektaş; Merve Alpay; Ali Evren Tufan
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  5 in total

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