Georgios Filippou1,2, Carlo A Scirè3,4, Nemanja Damjanov3,4, Antonella Adinolfi3,4, Greta Carrara3,4, Valentina Picerno3,4, Carmela Toscano3,4, George A Bruyn3,4, Maria Antonietta D'Agostino3,4, Andrea Delle Sedie3,4, Emilio Filippucci3,4, Marwin Gutierrez3,4, Mihaela Micu3,4, Ingrid Möller3,4, Esperanza Naredo3,4, Carlos Pineda3,4, Francesco Porta3,4, Wolfgang A Schmidt3,4, Lene Terslev3,4, Violeta Vlad3,4, Pascal Zufferey3,4, Annamaria Iagnocco3,4. 1. From the University of Siena, Siena; Italian Society for Rheumatology (SIR) Epidemiology Unit, Milan; University of Pisa, Pisa; Università Politecnica delle Marche, Jesi; Internal Medicine Division, San Jacopo Hospital, Pistoia; Università degli Studi di Torino, Turin, Italy; University of Belgrade, Belgrade, Serbia; Department of Rheumatology, MC Groep, Lelystad, the Netherlands; APHP, Hôpital Ambroise Paré, Rheumatology Department, Boulogne-Billancourt; INSERM U1173, Laboratoire d'Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France; Division of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de Rehabilitacion Luis Guillermo Ibarra Ibarra, Mexico City, Mexico; Rehabilitation Clinical Hospital, Cluj-Napoca; Sf. Maria Hospital, Bucharest, Romania; Instituto Poal, University of Barcelona, Barcelona; Department of Rheumatology, Joint and Bone Research Unit, Hospital Universitario Fundación Jimenez Deaz and Autónoma University, Madrid, Spain; Immanuel Krankenhaus Berlin, Medical Center for Rheumatology Berlin-Buch Berlin, Berlin, Germany; Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark; Lausanne University Hospital, Lausanne, Switzerland. gf.filippou@gmail.com. 2. G. Filippou, MD, PhD, University of Siena; C.A. Scirè, MD, Professor of Rheumatology, SIR Epidemiology Unit; N. Damjanov, MD, PhD, Professor of Rheumatology, University of Belgrade; A. Adinolfi, MD, University of Siena; G. Carrara, MSc, SIR Epidemiology Unit; V. Picerno, MD, University of Siena; C. Toscano, MD, University of Siena; G.A. Bruyn, MD, Professor of Rheumatology, Department of Rheumatology, MC Groep; M.A. D'Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department, and INSERM U1173, Laboratoire d'Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University; A. Delle Sedie, MD, University of Pisa; E. Filippucci, MD, PhD, Senior Lecturer in Rheumatology, Università Politecnica delle Marche; M. Gutierrez, MD, Division of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de Rehabilitacion Luis Guillermo Ibarra Ibarra; M. Micu, MD, Rehabilitation Clinical Hospital; I. Möller, MD, PhD, Instituto Poal, University of Barcelona; E. Naredo, MD, Department of Rheumatology, Joint and Bone Research Unit, Hospital Universitario Fundación Jimenez Deaz and Autónoma University; C. Pineda, MD, PhD, Division of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de Rehabilitacion Luis Guillermo Ibarra Ibarra; F. Porta, MD, Internal Medicine Division, San Jacopo Hospital; W.A. Schmidt, MD, Professor of Charité University Medicine, Immanuel Krankenhaus Berlin, Medical Center for Rheumatology Berlin-Buch; L. Terslev, MD, PhD, Center for Rheumatology and Spine Diseases, Rigshospitalet; V. Vlad, MD, PhD, Sf. Maria Hospital; P. Zufferey, MD, Lausanne University Hospital; A. Iagnocco, MD, Professor of Rheumatology, Università degli Studi di Torino. gf.filippou@gmail.com. 3. From the University of Siena, Siena; Italian Society for Rheumatology (SIR) Epidemiology Unit, Milan; University of Pisa, Pisa; Università Politecnica delle Marche, Jesi; Internal Medicine Division, San Jacopo Hospital, Pistoia; Università degli Studi di Torino, Turin, Italy; University of Belgrade, Belgrade, Serbia; Department of Rheumatology, MC Groep, Lelystad, the Netherlands; APHP, Hôpital Ambroise Paré, Rheumatology Department, Boulogne-Billancourt; INSERM U1173, Laboratoire d'Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, Saint-Quentin en Yvelines, France; Division of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de Rehabilitacion Luis Guillermo Ibarra Ibarra, Mexico City, Mexico; Rehabilitation Clinical Hospital, Cluj-Napoca; Sf. Maria Hospital, Bucharest, Romania; Instituto Poal, University of Barcelona, Barcelona; Department of Rheumatology, Joint and Bone Research Unit, Hospital Universitario Fundación Jimenez Deaz and Autónoma University, Madrid, Spain; Immanuel Krankenhaus Berlin, Medical Center for Rheumatology Berlin-Buch Berlin, Berlin, Germany; Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark; Lausanne University Hospital, Lausanne, Switzerland. 4. G. Filippou, MD, PhD, University of Siena; C.A. Scirè, MD, Professor of Rheumatology, SIR Epidemiology Unit; N. Damjanov, MD, PhD, Professor of Rheumatology, University of Belgrade; A. Adinolfi, MD, University of Siena; G. Carrara, MSc, SIR Epidemiology Unit; V. Picerno, MD, University of Siena; C. Toscano, MD, University of Siena; G.A. Bruyn, MD, Professor of Rheumatology, Department of Rheumatology, MC Groep; M.A. D'Agostino, MD, PhD, APHP, Hôpital Ambroise Paré, Rheumatology Department, and INSERM U1173, Laboratoire d'Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University; A. Delle Sedie, MD, University of Pisa; E. Filippucci, MD, PhD, Senior Lecturer in Rheumatology, Università Politecnica delle Marche; M. Gutierrez, MD, Division of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de Rehabilitacion Luis Guillermo Ibarra Ibarra; M. Micu, MD, Rehabilitation Clinical Hospital; I. Möller, MD, PhD, Instituto Poal, University of Barcelona; E. Naredo, MD, Department of Rheumatology, Joint and Bone Research Unit, Hospital Universitario Fundación Jimenez Deaz and Autónoma University; C. Pineda, MD, PhD, Division of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de Rehabilitacion Luis Guillermo Ibarra Ibarra; F. Porta, MD, Internal Medicine Division, San Jacopo Hospital; W.A. Schmidt, MD, Professor of Charité University Medicine, Immanuel Krankenhaus Berlin, Medical Center for Rheumatology Berlin-Buch; L. Terslev, MD, PhD, Center for Rheumatology and Spine Diseases, Rigshospitalet; V. Vlad, MD, PhD, Sf. Maria Hospital; P. Zufferey, MD, Lausanne University Hospital; A. Iagnocco, MD, Professor of Rheumatology, Università degli Studi di Torino.
Abstract
OBJECTIVE: To define the ultrasonographic characteristics of calcium pyrophosphate crystal (CPP) deposits in joints and periarticular tissues and to evaluate the intra- and interobserver reliability of expert ultrasonographers in the assessment of CPP deposition disease (CPPD) according to the new definitions. METHODS: After a systematic literature review, a Delphi survey was circulated among a group of expert ultrasonographers, who were members of the CPPD Ultrasound (US) Outcome Measures in Rheumatology (OMERACT) subtask force, to obtain definitions of the US characteristics of CPPD at the level of fibrocartilage (FC), hyaline cartilage (HC), tendon, and synovial fluid (SF). Subsequently, the reliability of US in assessing CPPD at knee and wrist levels according to the agreed definitions was tested in static images and in patients with CPPD. Cohen's κ was used for statistical analysis. RESULTS: HC and FC of the knee yielded the highest interobserver κ values among all the structures examined, in both the Web-based (0.73 for HC and 0.58 for FC) and patient-based exercises (0.55 for the HC and 0.64 for the FC). Kappa values for the other structures were lower, ranging from 0.28 in tendons to 0.50 in SF in the static exercise and from 0.09 (proximal patellar tendon) to 0.27 (triangular FC of the wrist) in the patient-based exercise. CONCLUSION: The new OMERACT definitions for the US identification of CPPD proved to be reliable at the level of the HC and FC of the knee. Further studies are needed to better define the US characteristics of CPPD and optimize the scanning technique in other anatomical sites.
OBJECTIVE: To define the ultrasonographic characteristics of calcium pyrophosphate crystal (CPP) deposits in joints and periarticular tissues and to evaluate the intra- and interobserver reliability of expert ultrasonographers in the assessment of CPP deposition disease (CPPD) according to the new definitions. METHODS: After a systematic literature review, a Delphi survey was circulated among a group of expert ultrasonographers, who were members of the CPPD Ultrasound (US) Outcome Measures in Rheumatology (OMERACT) subtask force, to obtain definitions of the US characteristics of CPPD at the level of fibrocartilage (FC), hyaline cartilage (HC), tendon, and synovial fluid (SF). Subsequently, the reliability of US in assessing CPPD at knee and wrist levels according to the agreed definitions was tested in static images and in patients with CPPD. Cohen's κ was used for statistical analysis. RESULTS: HC and FC of the knee yielded the highest interobserver κ values among all the structures examined, in both the Web-based (0.73 for HC and 0.58 for FC) and patient-based exercises (0.55 for the HC and 0.64 for the FC). Kappa values for the other structures were lower, ranging from 0.28 in tendons to 0.50 in SF in the static exercise and from 0.09 (proximal patellar tendon) to 0.27 (triangular FC of the wrist) in the patient-based exercise. CONCLUSION: The new OMERACT definitions for the US identification of CPPD proved to be reliable at the level of the HC and FC of the knee. Further studies are needed to better define the US characteristics of CPPD and optimize the scanning technique in other anatomical sites.
Authors: Sara K Tedeschi; Fabio Becce; Tristan Pascart; Ali Guermazi; Jean-François Budzik; Nicola Dalbeth; Georgios Filippou; Annamaria Iagnocco; Minna J Kohler; Jean-Denis Laredo; Stacy E Smith; F Joseph Simeone; Janeth Yinh; Hyon Choi; Abhishek Abhishek Journal: Arthritis Care Res (Hoboken) Date: 2022-04-19 Impact factor: 5.178
Authors: Nadiya V Yerich; Carolina Alvarez; Todd A Schwartz; Serena Savage-Guin; Jordan B Renner; Catherine J Bakewell; Minna J Kohler; Janice Lin; Jonathan Samuels; Amanda E Nelson Journal: ACR Open Rheumatol Date: 2020-06-29
Authors: Stavros Chrysidis; Christina Duftner; Christian Dejaco; Valentin S Schäfer; Sofia Ramiro; Greta Carrara; Carlo Alberto Scirè; Alojzija Hocevar; Andreas P Diamantopoulos; Annamaria Iagnocco; Chetan Mukhtyar; Cristina Ponte; Esperanza Naredo; Eugenio De Miguel; George A Bruyn; Kenneth J Warrington; Lene Terslev; Marcin Milchert; Maria Antonietta D'Agostino; Mattew J Koster; Naina Rastalsky; Petra Hanova; Pierluigi Macchioni; Tanaz A Kermani; Tove Lorenzen; Uffe Møller Døhn; Ulrich Fredberg; Wolfgang Hartung; Bhaskar Dasgupta; Wolfgang A Schmidt Journal: RMD Open Date: 2018-05-17