Literature DB >> 28249229

Differentiation and characterization of rhesus monkey atrial and ventricular cardiomyocytes from induced pluripotent stem cells.

Xiaoqian Zhang1, Henghua Cao2, Shuyun Bai1, Weibang Huo1, Yue Ma3.   

Abstract

The combination of non-human primate animals and their induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) provides not only transplantation models for cell-based therapy of heart diseases, but also opportunities for heart-related drug research on both cellular and animal levels. However, the subtypes and electrophysiology properties of non-human primate iPSC-CMs hadn't been detailed characterized. In this study, we generated rhesus monkey induced pluripotent stem cells (riPSCs), and efficiently differentiated them into ventricular or atrial cardiomyocytes by modulating retinoic acid (RA) pathways. Our results revealed that the electrophysiological characteristics and response to canonical drugs of riPSC-CMs were similar with those of human pluripotent stem cell derived CMs. Therefore, rhesus monkeys and their iPSC-CMs provide a powerful and practicable system for heart related biomedical research.
Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Atrial cardiomyocytes; Induced pluripotent stem cells; Rhesus monkey; Ventricular cardiomyocytes

Mesh：

Substances：

Year:  2017        PMID： 28249229     DOI： 10.1016/j.scr.2017.02.002

Source DB:  PubMed          Journal:  Stem Cell Res        ISSN： 1873-5061            Impact factor:   2.020


  7 in total

1.  Bone marrow mesenchymal stem cells combined with Sox2 increase the functional recovery in rat with traumatic brain injury.

Authors:  Qiang Hao; Jian Zheng; Yue Hu; Hao Wang
Journal:  Chin Neurosurg J       Date:  2019-05-15

2.  Efficient differentiation of cardiomyocytes and generation of calcium-sensor reporter lines from nonhuman primate iPSCs.

Authors:  Yongshun Lin; Huimin Liu; Michael Klein; John Ostrominski; So Gun Hong; Ravi Chandra Yada; Guibin Chen; Keron Navarengom; Robin Schwartzbeck; Hong San; Zu-Xi Yu; Chengyu Liu; Kaari Linask; Jeanette Beers; Lugui Qiu; Cynthia E Dunbar; Manfred Boehm; Jizhong Zou
Journal:  Sci Rep       Date:  2018-04-12       Impact factor: 4.379

3.  Non-Human Primate iPSC Generation, Cultivation, and Cardiac Differentiation under Chemically Defined Conditions.

Authors:  Michael Stauske; Ignacio Rodriguez Polo; Wadim Haas; Debbra Yasemin Knorr; Thomas Borchert; Katrin Streckfuss-Bömeke; Ralf Dressel; Iris Bartels; Malte Tiburcy; Wolfram-Hubertus Zimmermann; Rüdiger Behr
Journal:  Cells       Date:  2020-05-29       Impact factor: 6.600

4.  Retinoic acid promotes metabolic maturation of human Embryonic Stem Cell-derived Cardiomyocytes.

Authors:  Shumei Miao; Dandan Zhao; Xiaoxiao Wang; Xuan Ni; Xing Fang; Miao Yu; Lingqun Ye; Jingsi Yang; Hongchun Wu; Xinglong Han; Lina Qu; Lei Li; Feng Lan; Zhenya Shen; Wei Lei; Zhen-Ao Zhao; Shijun Hu
Journal:  Theranostics       Date:  2020-08-01       Impact factor: 11.556

5.  Baboon induced pluripotent stem cell generation by piggyBac transposition of reprogramming factors.

Authors:  Ignacio Rodriguez-Polo; Michael Stauske; Alexander Becker; Iris Bartels; Ralf Dressel; Rüdiger Behr
Journal:  Primate Biol       Date:  2019-07-29

6.  A piggyBac-based platform for genome editing and clonal rhesus macaque iPSC line derivation.

Authors:  Ignacio Rodriguez-Polo; Sophie Mißbach; Stoyan Petkov; Felix Mattern; Anna Maierhofer; Iga Grządzielewska; Yuliia Tereshchenko; Daniel Urrutia-Cabrera; Thomas Haaf; Ralf Dressel; Iris Bartels; Rüdiger Behr
Journal:  Sci Rep       Date:  2021-07-29       Impact factor: 4.379

Review 7.  Cardiac Cell Therapy with Pluripotent Stem Cell-Derived Cardiomyocytes: What Has Been Done and What Remains to Do?

Authors:  Dinesh Selvakumar; Leila Reyes; James J H Chong
Journal:  Curr Cardiol Rep       Date:  2022-03-11       Impact factor: 3.955
  7 in total

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