Katri V Typpo1, Hector R Wong, Stacey D Finley, Rodney C Daniels, Andrew J E Seely, Jacques Lacroix. 1. 1Department of Pediatrics and the Steele Children's Research Center, University of Arizona College of Medicine-Tucson, Tucson, AZ. 2Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH. 3Biomedical Engineering Department, Viterbi School of Engineering, University of Southern California, Los Angeles, CA. 4Department of Pediatrics and Communicable Diseases, C.S. Mott Children's Hospital, and Department of Biomedical Engineering, Michigan Center for Integrated Research in Critical Care, University of Michigan, Ann Arbor, MI. 5Division of Thoracic Surgery and Critical Care Medicine, Department of Surgery, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada. 6Division of Pediatric Critical Care Medicine, Department of Pediatrics, Sainte-Justine Hospital, Université de Montréal, Montréal, QC, Canada.
Abstract
OBJECTIVE: To describe new technologies (biomarkers and tests) used to assess and monitor the severity and progression of multiple organ dysfunction syndrome in children as discussed as part of the Eunice Kennedy Shriver National Institute of Child Health and Human Development MODS Workshop (March 26-27, 2015). DATA SOURCES: Literature review, research data, and expert opinion. STUDY SELECTION: Not applicable. DATA EXTRACTION: Moderated by an experienced expert from the field, investigators developing and assessing new technologies to improve the care and understanding of critical illness presented their research and the relevant literature. DATA SYNTHESIS: Summary of presentations and discussion supported and supplemented by relevant literature. CONCLUSIONS: There are many innovative tools and techniques with the potential application for the assessment and monitoring of severity of multiple organ dysfunction syndrome. If the reliability and added value of these candidate technologies can be established, they hold promise to enhance the understanding, monitoring, and perhaps, treatment of multiple organ dysfunction syndrome in children.
OBJECTIVE: To describe new technologies (biomarkers and tests) used to assess and monitor the severity and progression of multiple organ dysfunction syndrome in children as discussed as part of the Eunice Kennedy Shriver National Institute of Child Health and Human Development MODS Workshop (March 26-27, 2015). DATA SOURCES: Literature review, research data, and expert opinion. STUDY SELECTION: Not applicable. DATA EXTRACTION: Moderated by an experienced expert from the field, investigators developing and assessing new technologies to improve the care and understanding of critical illness presented their research and the relevant literature. DATA SYNTHESIS: Summary of presentations and discussion supported and supplemented by relevant literature. CONCLUSIONS: There are many innovative tools and techniques with the potential application for the assessment and monitoring of severity of multiple organ dysfunction syndrome. If the reliability and added value of these candidate technologies can be established, they hold promise to enhance the understanding, monitoring, and perhaps, treatment of multiple organ dysfunction syndrome in children.
Authors: Hector R Wong; Natalie Z Cvijanovich; Nick Anas; Geoffrey L Allen; Neal J Thomas; Michael T Bigham; Scott L Weiss; Julie Fitzgerald; Paul A Checchia; Keith Meyer; Thomas P Shanley; Michael Quasney; Mark Hall; Rainer Gedeit; Robert J Freishtat; Jeffrey Nowak; Shekhar S Raj; Shira Gertz; Emily Dawson; Kelli Howard; Kelli Harmon; Patrick Lahni; Erin Frank; Kimberly W Hart; Christopher J Lindsell Journal: Crit Care Med Date: 2015-08 Impact factor: 7.598
Authors: P J Godin; L A Fleisher; A Eidsath; R W Vandivier; H L Preas; S M Banks; T G Buchman; A F Suffredini Journal: Crit Care Med Date: 1996-07 Impact factor: 7.598
Authors: Bernard J Fisher; Donatas Kraskauskas; Erika J Martin; Daniela Farkas; Puneet Puri; H Davis Massey; Michael O Idowu; Donald F Brophy; Norbert F Voelkel; Alpha A Fowler; Ramesh Natarajan Journal: JPEN J Parenter Enteral Nutr Date: 2013-08-05 Impact factor: 4.016
Authors: Rajit K Basu; Stephen W Standage; Natalie Z Cvijanovich; Geoffrey L Allen; Neal J Thomas; Robert J Freishtat; Nick Anas; Keith Meyer; Paul A Checchia; Richard Lin; Thomas P Shanley; Michael T Bigham; Derek S Wheeler; Prasad Devarajan; Stuart L Goldstein; Hector R Wong Journal: Crit Care Date: 2011-11-18 Impact factor: 9.097
Authors: Hector R Wong; Scott L Weiss; John S Giuliano; Mark S Wainwright; Natalie Z Cvijanovich; Neal J Thomas; Geoffrey L Allen; Nick Anas; Michael T Bigham; Mark Hall; Robert J Freishtat; Anita Sen; Keith Meyer; Paul A Checchia; Thomas P Shanley; Jeffrey Nowak; Michael Quasney; Arun Chopra; Julie C Fitzgerald; Rainer Gedeit; Sharon Banschbach; Eileen Beckman; Patrick Lahni; Kimberly Hart; Christopher J Lindsell Journal: PLoS One Date: 2014-01-29 Impact factor: 3.240
Authors: Andrew J E Seely; Andrea Bravi; Christophe Herry; Geoffrey Green; André Longtin; Tim Ramsay; Dean Fergusson; Lauralyn McIntyre; Dalibor Kubelik; Donna E Maziak; Niall Ferguson; Samuel M Brown; Sangeeta Mehta; Claudio Martin; Gordon Rubenfeld; Frank J Jacono; Gari Clifford; Anna Fazekas; John Marshall Journal: Crit Care Date: 2014-04-08 Impact factor: 9.097
Authors: Mark J Peters; Andrew Argent; Marino Festa; Stéphane Leteurtre; Jefferson Piva; Ann Thompson; Douglas Willson; Pierre Tissières; Marisa Tucci; Jacques Lacroix Journal: Intensive Care Med Date: 2017-03-17 Impact factor: 17.440
Authors: Allan Doctor; Jill M Cholette; Kenneth E Remy; Andrew Argent; Jeffrey L Carson; Stacey L Valentine; Scot T Bateman; Jacques Lacroix Journal: Pediatr Crit Care Med Date: 2018-09 Impact factor: 3.624
Authors: Jeremy W Prokop; Rama Shankar; Ruchir Gupta; Mara L Leimanis; Derek Nedveck; Katie Uhl; Bin Chen; Nicholas L Hartog; Jason Van Veen; Joshua S Sisco; Olivia Sirpilla; Todd Lydic; Brian Boville; Angel Hernandez; Chi Braunreiter; ChiuYing Cynthia Kuk; Varinder Singh; Joshua Mills; Marc Wegener; Marie Adams; Mary Rhodes; Andre S Bachmann; Wenjing Pan; Miranda L Byrne-Steele; D Casey Smith; Mollye Depinet; Brittany E Brown; Mary Eisenhower; Jian Han; Marcus Haw; Casey Madura; Dominic J Sanfilippo; Laurie H Seaver; Caleb Bupp; Surender Rajasekaran Journal: Physiol Genomics Date: 2020-05-21 Impact factor: 3.107