PURPOSE: The aim of the study was to investigate blood flow in choroidal neovascular membrane in remission phase of neovascular age-related macular degeneration using optical coherence tomography (OCT) angiography. METHODS: OCT angiography was obtained in eyes with remission phase of neovascular age-related macular degeneration after treatments, defined as no exudative change (such as macular edema, subretinal fluid, and subretinal hemorrhage) observed in eyes without any treatment for neovascular age-related macular degeneration within the previous 6 months. Irregular blood flows shown in the segmentation of outer retina detected by OCT angiography were considered as blood flows in choroidal neovascular membrane. The vascular area and vessel density were obtained from OCT angiography images. RESULTS: Twenty eyes of 20 patients were included in this analysis. The blood flows in choroidal neovascular membrane were observed in all eyes (100%) using OCT angiography. The mean vascular area was 3.81 ± 3.41 mm and the mean vessel density of lesion was 28.9 ± 8.2%. The vessel density was significantly correlated with best-corrected visual acuity and duration of remission (best-corrected visual acuity: P = 0.008, r = -0.576; duration of remission: P = 0.017, r = -0.525, respectively). CONCLUSION: Optical coherence tomography angiography revealed that blood flows in choroidal neovascular membrane remained in eyes with clinically inactive neovascular age-related macular degeneration.
PURPOSE: The aim of the study was to investigate blood flow in choroidal neovascular membrane in remission phase of neovascular age-related macular degeneration using optical coherence tomography (OCT) angiography. METHODS: OCT angiography was obtained in eyes with remission phase of neovascular age-related macular degeneration after treatments, defined as no exudative change (such as macular edema, subretinal fluid, and subretinal hemorrhage) observed in eyes without any treatment for neovascular age-related macular degeneration within the previous 6 months. Irregular blood flows shown in the segmentation of outer retina detected by OCT angiography were considered as blood flows in choroidal neovascular membrane. The vascular area and vessel density were obtained from OCT angiography images. RESULTS: Twenty eyes of 20 patients were included in this analysis. The blood flows in choroidal neovascular membrane were observed in all eyes (100%) using OCT angiography. The mean vascular area was 3.81 ± 3.41 mm and the mean vessel density of lesion was 28.9 ± 8.2%. The vessel density was significantly correlated with best-corrected visual acuity and duration of remission (best-corrected visual acuity: P = 0.008, r = -0.576; duration of remission: P = 0.017, r = -0.525, respectively). CONCLUSION: Optical coherence tomography angiography revealed that blood flows in choroidal neovascular membrane remained in eyes with clinically inactive neovascular age-related macular degeneration.
Authors: Cynthia A Toth; Vincent Tai; Maxwell Pistilli; Stephanie J Chiu; Katrina P Winter; Ebenezer Daniel; Juan E Grunwald; Glenn J Jaffe; Daniel F Martin; Gui-Shuang Ying; Sina Farsiu; Maureen G Maguire Journal: Ophthalmol Retina Date: 2018-12-03
Authors: Atsuro Uchida; Ming Hu; Amy Babiuch; Sunil K Srivastava; Rishi P Singh; Peter K Kaiser; Katherine Talcott; Aleksandra Rachitskaya; Justis P Ehlers Journal: PLoS One Date: 2019-06-25 Impact factor: 3.240
Authors: Pedro Neves Cardoso; Ana Fernanda Pinheiro; Jorge Meira; Ana Catarina Pedrosa; Manuel S Falcão; João Pinheiro-Costa; Fernando Falcão-Reis; Ângela M Carneiro Journal: J Ophthalmol Date: 2017-10-19 Impact factor: 1.909