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Literature DB >> 2824855

A retrovirus carrying the polyomavirus middle T gene induces acute thrombocythemic myeloproliferative disease in mice.

A Fusco¹, G Portella, M Grieco, G Tajana, G Di Minno, N Polli, A Pinto.

Abstract

Mice inoculated with an artificially constructed retrovirus carrying the middle T gene of polyomavirus develop acute myeloproliferative disease with severe thrombotic and hemorrhagic disorder and impaired platelet function. The megakaryocytic lineage appears to be a target for polyoma-murine leukemia virus infection and middle T gene expression. This newly described disease represents a unique model system for studying disorders of the megakaryocytic lineage.

Entities: Disease Species

Mesh：

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Year: 1988 PMID： 2824855 PMCID： PMC250540 DOI： 10.1128/JVI.62.1.361-365.1988

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

14 in total

Review 1. Editorial: Spleen focus-forming virus in Friend and Rauscher leukemia virus preparations.

Authors: R A Steeves
Journal: J Natl Cancer Inst Date: 1975-02 Impact factor: 13.506

2. Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts.

Authors: S L Adams; M E Sobel; B H Howard; K Olden; K M Yamada; B de Crombrugghe; I Pastan
Journal: Proc Natl Acad Sci U S A Date: 1977-08 Impact factor: 11.205

A retrovirus carrying the polyomavirus middle T gene induces acute thrombocythemic myeloproliferative disease in mice.

Review 1. Editorial: Spleen focus-forming virus in Friend and Rauscher leukemia virus preparations.

2. Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts.

3. Interleukin 3 promotes the differentiation of isolated single megakaryocytes.

4. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

5. Transmission of the polyoma virus middle T gene as the oncogene of a murine retrovirus.

6. Construction and functional characterization of polyomavirus genomes that separately encode the three early proteins.

7. Immature Megakaryocytes in the Mouse: Morphology and quantitation by acetylcholinesterase staining.

8. A liquid culture system for murine megakaryocyte progenitor cells.

9. Platelet function in patients with high platelet counts.

10. Protein kinase activities associated with distinct antigenic forms of polyoma virus middle T-antigen.

Review 1. Natural biology of polyomavirus middle T antigen.

2. Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization.

3. Intermittent high glucose induces pyroptosis of rat H9C2 cardiomyocytes via sodium-glucose cotransporter 1.

Review 4. Toward targeting inflammasomes: insights into their regulation and activation.