| Literature DB >> 28248497 |
Zosia A M Zielinski1, Derek A Pratt1.
Abstract
Recent advances in our understanding of lipid peroxidation, a degenerative process that is believed to play a key role in the pathogenesis of many diseases, are highlighted. In particular, the factors that control the kinetics and regio-/stereochemical outcomes of the autoxidation of both polyunsaturated fatty acids and sterols and the subsequent decomposition of the hydroperoxide products to cytotoxic derivatives are discussed. These advances promise to help clarify the role of lipid peroxidation in cell death and human disease.Entities:
Mesh:
Substances:
Year: 2017 PMID: 28248497 DOI: 10.1021/acs.joc.7b00152
Source DB: PubMed Journal: J Org Chem ISSN: 0022-3263 Impact factor: 4.354