Amy L D'Agata1,2, Stephen Walsh1, Dorothy Vittner1,3, Xiaomei Cong1, Jacqueline M McGrath1,4, Erin E Young1,5,6. 1. School of Nursing, University of Connecticut, Storrs, Connecticut. 2. College of Nursing, University of South Florida, Tampa, Florida. 3. Division of Quality Management, Connecticut Department of Developmental Services, Hartford, Connecticut. 4. Connecticut Children's Medical Center, Hartford, Connecticut. 5. Institute for Systems Genomics, University of Connecticut, Storrs, Connecticut. 6. School of Medicine, Genetics and Genome Sciences, University of Connecticut, Farmington, Connecticut.
Abstract
PROBLEM: This study evaluated the relationship between stressful early life neonatal intensive care unit (NICU) experiences, genetic variation of a stress response-associated gene (FKBP5), and neurobehavioral outcomes. METHOD: The impact of genetic variation and stress experience on neurobehavioral outcomes was examined for 41 preterm infants. Statistical analyses explored the main effects of FKBP5 genotype and NICU stress experience, as well as their interaction on infant neurobehavioral development prior to discharge. RESULTS: Statistical analyses demonstrated a relationship between both FKPB5 genotype and stress related to NICU care that were independently associated with neurobehavioral outcomes; indicating a main effect of genotype and a main effect of stress on neurodevelopment. Additionally, we found an interaction between the minor allele genotype and NICU stress potentially associated with less favorable developmental progress at discharge. IMPLICATIONS: Evidence of genetic and environmental risk factors for neurodevelopmental impairment suggests the need for improved evidence-based practice initiatives to protect those most vulnerable to the combination of genetic susceptibility to stress and medical fragility.
PROBLEM: This study evaluated the relationship between stressful early life neonatal intensive care unit (NICU) experiences, genetic variation of a stress response-associated gene (FKBP5), and neurobehavioral outcomes. METHOD: The impact of genetic variation and stress experience on neurobehavioral outcomes was examined for 41 preterm infants. Statistical analyses explored the main effects of FKBP5 genotype and NICU stress experience, as well as their interaction on infant neurobehavioral development prior to discharge. RESULTS: Statistical analyses demonstrated a relationship between both FKPB5 genotype and stress related to NICU care that were independently associated with neurobehavioral outcomes; indicating a main effect of genotype and a main effect of stress on neurodevelopment. Additionally, we found an interaction between the minor allele genotype and NICU stress potentially associated with less favorable developmental progress at discharge. IMPLICATIONS: Evidence of genetic and environmental risk factors for neurodevelopmental impairment suggests the need for improved evidence-based practice initiatives to protect those most vulnerable to the combination of genetic susceptibility to stress and medical fragility.
Authors: Amy L D'Agata; Jing Wu; Manushi K V Welandawe; Samia V O Dutra; Bradley Kane; Maureen W Groer Journal: Dev Psychobiol Date: 2019-01-30 Impact factor: 3.038
Authors: Marangelie Criado-Marrero; Theo Rein; Elisabeth B Binder; James T Porter; John Koren; Laura J Blair Journal: Philos Trans R Soc Lond B Biol Sci Date: 2018-01-19 Impact factor: 6.237