Literature DB >> 28247133

Inhibitors of the cleavage of aclacinomycins.

U Gräfe1, K Dornberger1, W F Fleck1, G Schumann1.   

Abstract

The reductive cleavage of the aclacinomycins A (I), Y (II), and B (III) by intact mycelia or subcellular fractions of the producer strain S. spec. AM 33352/F43 is suppressed in the presence of uncouplers, complex-forming agents, detergents, and some metal anions such as chromate. Increased concentration of the latter in complete cultures caused rearrangement of I to III.

Entities:  

Year:  1987        PMID： 28247133     DOI： 10.1007/BF01026192

Source DB:  PubMed          Journal:  Biotechnol Lett        ISSN： 0141-5492            Impact factor:   2.461


  5 in total

1.  New antitumor antibiotics aclacinomycins A and B.

Authors:  T Oki; Y Matsuzawa; A Yoshimoto; K Numata; I Kitamura
Journal:  J Antibiot (Tokyo)       Date:  1975-10       Impact factor: 2.649

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  Reductive microbial conversion of anthracycline antibiotics.

Authors:  V P Marshall; E A Reisender; L M Reineke; J H Johnson; P F Wiley
Journal:  Biochemistry       Date:  1976-09-21       Impact factor: 3.162

4.  Reduction of anthracycline glycoside by NADPH--cytochrome P-450 reductase.

Authors:  T Komiyama; T Oki; T Inui; T Takeuchi; H Umezawa
Journal:  Gan       Date:  1979-08

5.  Antitumor anthracycline antibiotics, aclacinomycin A and analogues. I. Taxonomy, production, isolation and physicochemical properties.

Authors:  T Oki; I Kitamura; A Yoshimoto; Y Matsuzawa; N Shibamoto; T Ogasawara; T Inui; A Takamatsu; T Takeuchi; T Masuda; M Hamada; H Suda; M Ishizuka; T Sawa; H Umezawa
Journal:  J Antibiot (Tokyo)       Date:  1979-08       Impact factor: 2.649
  5 in total

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