Amitabh Jha1, Prabhu P Mohapatra1, Salma A AlHarbi1, Nusrat Jahan1.
Abstract
BACKGROUND: This is a short review on the most recent studies on curcumin and its analogs, including the studies from the laboratories of authors. The diverse medicinal properties of curcumin itself reported in the recent years are reviewed. Although curcumin has shown great potential in treating various diseases, it has not been approved as a clinical drug candidate because of its poor pharmacokinetics.
METHOD: The recent methods developed to solve this problem are briefly described.
CONCLUSION: The biological and other properties of synthetic curcumin analogs (diarylheptanoids and diarylpentanoid monocarbonyl derivatives) reported in the recent literature are also presented. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND: This is a short review on the most recent studies on curcumin and its analogs, including the studies from the laboratories of authors. The diverse medicinal properties of curcumin itself reported in the recent years are reviewed. Although curcumin has shown great potential in treating various diseases, it has not been approved as a clinical drug candidate because of its poor pharmacokinetics.
METHOD: The recent methods developed to solve this problem are briefly described.
CONCLUSION: The biological and other properties of synthetic curcumin analogs (diarylheptanoids and diarylpentanoid monocarbonyl derivatives) reported in the recent literature are also presented. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities:
Keywords:
Anticancer; Michael acceptor; antioxidant; curcumin; curcumin analogs; diarylheptanoids; diarylpentanoids; formulations; mechanismzzm321990of action; pharmacokinetics; topoisomerase IIα inhibitors.
Mesh：
Substances：
Year: 2017
PMID： 28245778 DOI： 10.2174/1389557517666170228114234
Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862