BACKGROUND/AIMS: Neuropsychiatric symptoms (NPS) are common in Alzheimer disease (AD) and vascular dementia (VaD), and are distressful to patients and caregivers. NPS are likely related to the underlying pathology. Previous studies suggest that frontal lobe lesions and vascular changes such as white matter hyperintensities (WMH) have a significant association with specific NPS. The current study aimed to compare NPS in patients with AD, VaD, and mixed AD/VaD, and to evaluate the differences in the prevalence of NPS in relation to frontal WMH volume. METHODS: In total, 180 patients with NPS and MRI data (92 probable AD, 51%; 34 probable VaD, 19%; and 54 probable mixed AD/VaD, 30%) were included in the study. Regression analyses were performed to determine the relationships between NPS prevalence and diagnosis, and between NPS and frontal WMH. RESULTS: VaD patients had significantly more agitation (p < 0.05; 40 vs. 14%) and sleep disturbances (p < 0.05; 57 vs. 32%) than AD patients, and significantly more depression (p < 0.05; 48 vs. 20%) and aberrant motor behaviors (p < 0.05; 31 vs. 13%) than mixed AD/VaD patients. AD patients with delusions had significantly greater right frontal WMH volumes than those without (p < 0.05; delusions 1/0 = 314.8/112.6 mm3). CONCLUSION: Differences in NPS prevalence are likely related to the underlying pathology and warrant further study as they have implications for treatment.
BACKGROUND/AIMS: Neuropsychiatric symptoms (NPS) are common in Alzheimer disease (AD) and vascular dementia (VaD), and are distressful to patients and caregivers. NPS are likely related to the underlying pathology. Previous studies suggest that frontal lobe lesions and vascular changes such as white matter hyperintensities (WMH) have a significant association with specific NPS. The current study aimed to compare NPS in patients with AD, VaD, and mixed AD/VaD, and to evaluate the differences in the prevalence of NPS in relation to frontal WMH volume. METHODS: In total, 180 patients with NPS and MRI data (92 probable AD, 51%; 34 probable VaD, 19%; and 54 probable mixed AD/VaD, 30%) were included in the study. Regression analyses were performed to determine the relationships between NPS prevalence and diagnosis, and between NPS and frontal WMH. RESULTS: VaD patients had significantly more agitation (p < 0.05; 40 vs. 14%) and sleep disturbances (p < 0.05; 57 vs. 32%) than ADpatients, and significantly more depression (p < 0.05; 48 vs. 20%) and aberrant motor behaviors (p < 0.05; 31 vs. 13%) than mixed AD/VaD patients. ADpatients with delusions had significantly greater right frontal WMH volumes than those without (p < 0.05; delusions 1/0 = 314.8/112.6 mm3). CONCLUSION: Differences in NPS prevalence are likely related to the underlying pathology and warrant further study as they have implications for treatment.
Authors: Anna E. Leeuwis; Nick A. Weaver; J. Matthijs Biesbroek; Lieza G. Exalto; Hugo J. Kuijf; Astrid M. Hooghiemstra; Niels D. Prins; Philip Scheltens; Frederik Barkhof; Wiesje M. van der Flier; Geert Jan Biessels Journal: J Psychiatry Neurosci Date: 2019-07-01 Impact factor: 6.186
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Authors: Miracle Ozzoude; Brenda Varriano; Derek Beaton; Joel Ramirez; Melissa F Holmes; Christopher J M Scott; Fuqiang Gao; Kelly M Sunderland; Paula McLaughlin; Jennifer Rabin; Maged Goubran; Donna Kwan; Angela Roberts; Robert Bartha; Sean Symons; Brian Tan; Richard H Swartz; Agessandro Abrahao; Gustavo Saposnik; Mario Masellis; Anthony E Lang; Connie Marras; Lorne Zinman; Christen Shoesmith; Michael Borrie; Corinne E Fischer; Andrew Frank; Morris Freedman; Manuel Montero-Odasso; Sanjeev Kumar; Stephen Pasternak; Stephen C Strother; Bruce G Pollock; Tarek K Rajji; Dallas Seitz; David F Tang-Wai; John Turnbull; Dar Dowlatshahi; Ayman Hassan; Leanne Casaubon; Jennifer Mandzia; Demetrios Sahlas; David P Breen; David Grimes; Mandar Jog; Thomas D L Steeves; Stephen R Arnott; Sandra E Black; Elizabeth Finger; Maria Carmela Tartaglia Journal: Geroscience Date: 2022-03-16 Impact factor: 7.581
Authors: Emily J Tomlinson; Helen Rawson; Elizabeth Manias; Nicole Nikki M Phillips; Peteris Darzins; Alison M Hutchinson Journal: BMJ Open Date: 2021-07-07 Impact factor: 2.692