| Literature DB >> 2824475 |
W de Wet1, M Bernard, V Benson-Chanda, M L Chu, L Dickson, D Weil, F Ramirez.
Abstract
Sixty kilobases of cloned DNA containing the entire human pro-alpha 2(I) collagen gene and 22 kilobases of flanking sequences have been isolated. Like the homologous avian gene, the 1366 amino acid residues of the human pre-pro-alpha 2(I) chain are encoded by 52 exons, whose relative locations and sizes have been determined. Analysis of the 5'- and 3'-untranslated regions have confirmed their exact lengths, as well as conclusively established the nature of five polymorphic mRNA transcripts.Entities:
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Year: 1987 PMID： 2824475
Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157