Yuan-Qing Fu1,2, Hong Yang3, Ju-Sheng Zheng1, Xiao-Yun Zeng3, Wen Zeng3, Zhi-Fen Fan3, Min Chen3, Ling Wang4, Duo Li5. 1. Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China. 2. Department of Maternal and Infant Nutrition, Beingmate Food Research Institute Co., Ltd, Hangzhou, China. 3. Wuhan Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 4. College of Food Science and Technology, Huazhong Agricultural University, Wuhan, China. 5. Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China. Email: duoli@zju.edu.cn.
Abstract
BACKGROUND AND OBJECTIVES: The objective was to determine whether serum uric acid concentrations were associated with metabolic syndrome in a population from Wuhan. METHODS AND STUDY DESIGN: 5,628 subjects (2,838 men, 2,790 women) aged 18-80 years were recruited in Wuhan, China. Biochemical parameters of venous blood were measured by standard methods and metabolic syndrome was defined by Chinese Diabetes Society criteria. Association analysis was performed by logistic regression. RESULTS: 8.2% of the included subjects were confirmed as having metabolic syndrome and 14.4% were confirmed as having hyperuricemia. After multivariable adjustment, logistic regression showed the odds ratios of metabolic syndrome for subjects in the highest quartile of serum uric acid concentration was 2.84 (95% CI: 2.09-3.86) compared with those in the lowest quartile and no gender difference was found. For each component of metabolic syndrome, subjects in the highest quartile of serum uric acid concentrations had increased multivariable odds ratios for high BMI (OR: 3.29, 95% CI: 2.71-3.98), for hypertension (OR: 3.54, 95% CI: 2.93-3.86), for dyslipidemia (OR: 2.49, 95% CI: 1.98-3.14), but not for hyperglycemia (OR: 1.21, 95% CI: 0.87-1.67). CONCLUSIONS: Odd ratio of metabolic syndrome was significantly positively associated with serum uric acid concentration among the present sample of 5,628 subjects in Wuhan.
BACKGROUND AND OBJECTIVES: The objective was to determine whether serum uric acid concentrations were associated with metabolic syndrome in a population from Wuhan. METHODS AND STUDY DESIGN: 5,628 subjects (2,838 men, 2,790 women) aged 18-80 years were recruited in Wuhan, China. Biochemical parameters of venous blood were measured by standard methods and metabolic syndrome was defined by Chinese Diabetes Society criteria. Association analysis was performed by logistic regression. RESULTS: 8.2% of the included subjects were confirmed as having metabolic syndrome and 14.4% were confirmed as having hyperuricemia. After multivariable adjustment, logistic regression showed the odds ratios of metabolic syndrome for subjects in the highest quartile of serum uric acid concentration was 2.84 (95% CI: 2.09-3.86) compared with those in the lowest quartile and no gender difference was found. For each component of metabolic syndrome, subjects in the highest quartile of serum uric acid concentrations had increased multivariable odds ratios for high BMI (OR: 3.29, 95% CI: 2.71-3.98), for hypertension (OR: 3.54, 95% CI: 2.93-3.86), for dyslipidemia (OR: 2.49, 95% CI: 1.98-3.14), but not for hyperglycemia (OR: 1.21, 95% CI: 0.87-1.67). CONCLUSIONS: Odd ratio of metabolic syndrome was significantly positively associated with serum uric acid concentration among the present sample of 5,628 subjects in Wuhan.