Nalina Bhupornvivat1, Vorapong Phupong2. 1. Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. 2. Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Email: vorapong.p@chula.ac.th.
Abstract
BACKGROUND AND OBJECTIVES: Pregnancy complications hypothesized to be related to vitamin D include preeclampsia, gestational diabetes, low birth weight, preterm delivery, Cesarean section and infectious disease. There have been a few studies which have demonstrated maternal serum vitamin D to be associated with preterm labor. The objective was to evaluate the serum vitamin D concentrations in Thai pregnant women with and without preterm labor and to find the prevalence of vitamin D deficiency and insufficiency in both groups. METHODS AND STUDY DESIGN: Blood samples were collected from pregnant women with and without preterm labor (matched for gestational age). Serum 25-hydroxyvitamin D (25-OHD) concentrations were measured by chemiluminescence method. RESULTS: A total of 60 pregnant women were included into the study, 30 patients in the preterm labor group and another 30 patients in the control group. The serum 25-OHD concentration was 21.0±7.5 ng/mL and the prevalence of vitamin D deficiency was 48.3% in total group of pregnant women. The serum 25-OHD concentrations were not different between the preterm labor and the control groups (20.9±8.4 vs 21.2±6.7 ng/mL, p=0.91). The prevalence of vitamin D deficiency and insufficiency were not different between the preterm labor and the control groups (53.3% vs 43.3%, p=0.44 and 83.3% vs 90%, p=0.45, respectively). CONCLUSION: The serum 25-hydroxyvitamin D concentrations and the prevalence of vitamin D deficiency and insufficiency were not different between the preterm labor and the control groups. The serum 25-OHD could not predict preterm labor in this Thai population.
BACKGROUND AND OBJECTIVES: Pregnancy complications hypothesized to be related to vitamin D include preeclampsia, gestational diabetes, low birth weight, preterm delivery, Cesarean section and infectious disease. There have been a few studies which have demonstrated maternal serum vitamin D to be associated with preterm labor. The objective was to evaluate the serum vitamin D concentrations in Thai pregnant women with and without preterm labor and to find the prevalence of vitamin Ddeficiency and insufficiency in both groups. METHODS AND STUDY DESIGN: Blood samples were collected from pregnant women with and without preterm labor (matched for gestational age). Serum 25-hydroxyvitamin D (25-OHD) concentrations were measured by chemiluminescence method. RESULTS: A total of 60 pregnant women were included into the study, 30 patients in the preterm labor group and another 30 patients in the control group. The serum 25-OHD concentration was 21.0±7.5 ng/mL and the prevalence of vitamin D deficiency was 48.3% in total group of pregnant women. The serum 25-OHD concentrations were not different between the preterm labor and the control groups (20.9±8.4 vs 21.2±6.7 ng/mL, p=0.91). The prevalence of vitamin Ddeficiency and insufficiency were not different between the preterm labor and the control groups (53.3% vs 43.3%, p=0.44 and 83.3% vs 90%, p=0.45, respectively). CONCLUSION: The serum 25-hydroxyvitamin D concentrations and the prevalence of vitamin Ddeficiency and insufficiency were not different between the preterm labor and the control groups. The serum 25-OHD could not predict preterm labor in this Thai population.
Authors: Emma Ronde; Irwin K M Reiss; Thomas Hankemeier; Tim G De Meij; Nina Frerichs; Sam Schoenmakers Journal: Front Endocrinol (Lausanne) Date: 2021-09-06 Impact factor: 5.555