Literature DB >> 28244637

Blastic transformation of juvenile myelomonocytic leukemia caused by the copy number gain of oncogenic KRAS.

Tomoo Osumi1,2, Motohiro Kato1,2, Meri Ouchi-Uchiyama1, Daisuke Tomizawa2, Keisuke Kataoka3, Yoichi Fujii3, Masafumi Seki4, Junko Takita4, Seishi Ogawa3, Toru Uchiyama5, Kentaro Ohki1, Nobutaka Kiyokawa1.   

Abstract

Previous studies have reported several cases of juvenile myelomonocytic leukemia (JMML) developing blastic transformation during an indolent clinical course, but the underlying mechanism of transformation is still not well understood. In this report, we describe a case of JMML with blastic transformation possibly caused by additional copy number gains of the KRAS mutant allele. We have discovered that the copy number gain of the mutant allele is an additional possible cause of blastic transformation in JMML.
© 2017 Wiley Periodicals, Inc.

Entities:  

Keywords:  CNG; JMML; KRAS; blast crisis; duplication

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Year:  2017        PMID： 28244637     DOI： 10.1002/pbc.26496

Source DB:  PubMed          Journal:  Pediatr Blood Cancer        ISSN： 1545-5009            Impact factor:   3.167


  2 in total

Review 1.  JMML genomics and decisions.

Authors:  Charlotte M Niemeyer
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2018-11-30

2.  Sustained remission with azacitidine monotherapy and an aberrant precursor B-lymphoblast population in juvenile myelomonocytic leukemia.

Authors:  Saman K Hashmi; Jyotinder N Punia; Andrea N Marcogliese; Amos S Gaikwad; Kevin E Fisher; Angshumoy Roy; Pulivarthi Rao; Dolores H Lopez-Terrada; Jo Ringrose; Mignon L Loh; Charlotte M Niemeyer; Rachel E Rau
Journal:  Pediatr Blood Cancer       Date:  2019-06-28       Impact factor: 3.167
  2 in total

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