Literature DB >> 2824347

Pathways of human B-lymphocyte activation blocked by B-cell specific monoclonal antibodies.

J T Golay1, D H Crawford.   

Abstract

The data presented in this report demonstrate that antibodies directed against B-cell specific surface antigens can block different modes of B-cell activation. The anti-CD 19 antibody HD37 strongly blocks the stimulation of thymidine incorporation induced by anti-mu and MLR supernatant and also partially inhibits the growth of long-term EBV-transformed cell lines. The anti-CD20 antibody B1, on the other hand, has little effect on anti-mu activation but prevents the stimulation of thymidine incorporation and transformation by EBV. We conclude that different mechanisms operate during B-cell activation by anti-mu and EBV involving different B-cell surface molecules.

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Year:  1987        PMID： 2824347      PMCID： PMC1453973     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  10 in total

1.  Cellular localization of an Epstein-Barr virus (EBV)-associated complement-fixing antigen in producer and non-producer lymphoblastoid cell lines.

Authors:  B M Reedman; G Klein
Journal:  Int J Cancer       Date:  1973-05       Impact factor: 7.396

2.  Role of the Bp35 cell surface polypeptide in human B-cell activation.

Authors:  E A Clark; G Shu; J A Ledbetter
Journal:  Proc Natl Acad Sci U S A       Date:  1985-03       Impact factor: 11.205

3.  Activation of human B lymphocytes. II. Cellular interactions in the PFC response of human tonsillar and peripheral blood B lymphocytes to polyclonal activation by pokeweed mitogen.

Authors:  A S Fauci; K R Pratt; G Whalen
Journal:  J Immunol       Date:  1976-12       Impact factor: 5.422

4.  Effects of cyclosporin A on the immune system of the mouse. I. Evidence for a direct selective effect of cyclosporin A on B cells responding to anti-immunoglobulin antibodies.

Authors:  D W Dongworth; G G Klaus
Journal:  Eur J Immunol       Date:  1982-12       Impact factor: 5.532

5.  Differential expression of cell activation markers after stimulation of resting human B lymphocytes.

Authors:  J H Kehrl; A Muraguchi; A S Fauci
Journal:  J Immunol       Date:  1984-06       Impact factor: 5.422

6.  Proliferative responses of normal human B lymphocytes. Development of an assay system for human B cell growth factor (BCGF).

Authors:  A Muraguchi; A S Fauci
Journal:  J Immunol       Date:  1982-09       Impact factor: 5.422

7.  Relationship between immunoglobulin production and immortalization by Epstein Barr virus.

Authors:  G Tosato; R M Blaese; R Yarchoan
Journal:  J Immunol       Date:  1985-08       Impact factor: 5.422

8.  The CD20 (Bp35) antigen is involved in activation of B cells from the G0 to the G1 phase of the cell cycle.

Authors:  J T Golay; E A Clark; P C Beverley
Journal:  J Immunol       Date:  1985-12       Impact factor: 5.422

9.  Frequencies of the separate human B cell subsets activatable to Ig secretion by Epstein-Barr virus and pokeweed mitogen.

Authors:  O Martínez-Maza; S Britton
Journal:  J Exp Med       Date:  1983-06-01       Impact factor: 14.307

10.  Selective suppression of an early step in human B cell activation by cyclosporin A.

Authors:  A Muraguchi; J L Butler; J H Kehrl; R J Falkoff; A S Fauci
Journal:  J Exp Med       Date:  1983-09-01       Impact factor: 14.307
  10 in total
  6 in total

Review 1.  CD20-mediated apoptosis: signalling through lipid rafts.

Authors:  Julie P Deans; Haidong Li; Maria J Polyak
Journal:  Immunology       Date:  2002-10       Impact factor: 7.397

2.  The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP.

Authors:  Z Kozmik; S Wang; P Dörfler; B Adams; M Busslinger
Journal:  Mol Cell Biol       Date:  1992-06       Impact factor: 4.272

3.  An activation antigen on a subpopulation of B lymphocytes identified by the monoclonal antibody CMRF-17.

Authors:  S F Peach; S E Davidson; J L McKenzie; J C Nimmo; D N Hart
Journal:  Immunology       Date:  1989-07       Impact factor: 7.397

4.  Functional evaluation of CD19- and CD22-negative variants of B-lymphoid cell lines.

Authors:  S Kiesel; A Pezzutto; R Haas; G Moldenhauer; B Dörken
Journal:  Immunology       Date:  1988-07       Impact factor: 7.397

5.  Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes.

Authors:  J K Bubien; L J Zhou; P D Bell; R A Frizzell; T F Tedder
Journal:  J Cell Biol       Date:  1993-06       Impact factor: 10.539

6.  Viral interleukin 10 is critical for the induction of B cell growth transformation by Epstein-Barr virus.

Authors:  I Miyazaki; R K Cheung; H M Dosch
Journal:  J Exp Med       Date:  1993-08-01       Impact factor: 14.307
  6 in total

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