Esophageal ridges: an unusual complication of oral iron therapy.

A 60-year-old female who was being treated for anemia underwent esophagogastroduodenoscopy for evaluation of recent-onset dyspepsia. Endoscopy revealed two longitudinal esophageal ridges extending from the middle to the lower esophagus (Fig. 1). Multiple biopsies taken from these ridges showed deposits of brownish granular iron pigment in the lamina propria, covered by an intact epithelium (Fig. 2A), highlighted by iron stain (Fig. 2B). The patient reported taking oral iron supplementation for iron deficiency anemia for past 6 months. The patient was advised to stop oral iron, as her hemoglobin and iron profile were now normal. Endoscopy after three months showed a significant decrease in size of these ridges (Fig. 1B). Repeat biopsies revealed an absence of any iron stores.

Figure 1

(A) Esophageal ridges. (B) Reduction in size of lesions at 3 months

Figure 2

(A) Esophageal biopsy showing iron deposition in the lamina propria covered by an intact epithelium (hematoxylin and eosin X 400). (B) Iron deposition confirmed on iron stain (Perl’s Prussian blue X 200)

Endoscopic changes due to iron-induced injury may include the presence of gastrointestinal erythematous changes, erosions, subepithelial hemorrhages, color changes to brown or black dots (siderosis), ulcers, and rarely strictures [1,2]. The presence of iron in gastrointestinal biopsy specimens may be due to iron overload states, including hemochromatosis and multiple blood transfusions, as well as being secondary to iron supplementation [3]. One report has described the occurrence of a flat rounded pale lesion in the stomach, believed to be related to oral iron therapy [1]. The changes of the esophageal ridge-like lesions which we describe are hitherto unreported and add to the spectrum of gastrointestinal endoscopic findings related to oral iron ingestion.