AIMS: The aim of the present study was to investigate the effects of successful PCI CTO on absolute myocardial blood flow (MBF) and functional recovery. METHODS AND RESULTS: Patients with a documented CTO were prospectively examined for ischaemia and viability with [15O]H2O positron emission tomography (PET) and late gadolinium enhancement cardiac magnetic resonance imaging (LGE-CMR). Sixty-nine consecutive patients, in whom PCI was successful, underwent follow-up PET and CMR after approximately 12 weeks to evaluate potential improvement of MBF as well as systolic function. After PCI, stress MBF in the CTO area increased from 1.22±0.36 to 2.40±0.90 mL·min-1·g-1 (p<0.001), whilst stress MBF in the remote area also increased significantly between baseline and follow-up PET (2.58±0.68 to 2.77±0.77 mL·min-1·g-1, p=0.01). The ratio of stress MBF between CTO and remote area was 0.49±0.13 at baseline and increased to 0.87±0.24 at follow-up (p<0.001). The MBF defect size of the CTO area decreased from 5.12±1.69 to 1.91±1.75 myocardial segments after PCI (p<0.001). Left ventricular ejection fraction (LVEF) increased significantly (46.4±11.0 vs. 47.5±11.4%, p=0.01) at follow-up. CONCLUSIONS: The vast majority of CTO patients with documented ischaemia and viability showed significant improvement in stress MBF and a reduction of ischaemic burden after successful percutaneous revascularisation with only minimal effect on LVEF.
AIMS: The aim of the present study was to investigate the effects of successful PCI CTO on absolute myocardial blood flow (MBF) and functional recovery. METHODS AND RESULTS:Patients with a documented CTO were prospectively examined for ischaemia and viability with [15O]H2O positron emission tomography (PET) and late gadolinium enhancement cardiac magnetic resonance imaging (LGE-CMR). Sixty-nine consecutive patients, in whom PCI was successful, underwent follow-up PET and CMR after approximately 12 weeks to evaluate potential improvement of MBF as well as systolic function. After PCI, stress MBF in the CTO area increased from 1.22±0.36 to 2.40±0.90 mL·min-1·g-1 (p<0.001), whilst stress MBF in the remote area also increased significantly between baseline and follow-up PET (2.58±0.68 to 2.77±0.77 mL·min-1·g-1, p=0.01). The ratio of stress MBF between CTO and remote area was 0.49±0.13 at baseline and increased to 0.87±0.24 at follow-up (p<0.001). The MBF defect size of the CTO area decreased from 5.12±1.69 to 1.91±1.75 myocardial segments after PCI (p<0.001). Left ventricular ejection fraction (LVEF) increased significantly (46.4±11.0 vs. 47.5±11.4%, p=0.01) at follow-up. CONCLUSIONS: The vast majority of CTO patients with documented ischaemia and viability showed significant improvement in stress MBF and a reduction of ischaemic burden after successful percutaneous revascularisation with only minimal effect on LVEF.
Authors: Stefan P Schumacher; Roel S Driessen; Wijnand J Stuijfzand; Pieter G Raijmakers; Ibrahim Danad; Jo Dens; James C Spratt; Colm G Hanratty; Simon J Walsh; Ronald Boellaard; Albert C van Rossum; Maksymilian P Opolski; Alexander Nap; Paul Knaapen Journal: Catheter Cardiovasc Interv Date: 2018-11-15 Impact factor: 2.692
Authors: Teresa Vitadello; Karl P Kunze; Stephan G Nekolla; Nicolas Langwieser; Christian Bradaric; Florian Weis; Salvatore Cassese; Massimiliano Fusaro; Alexander Hapfelmeier; Thorsten Lewalter; Markus Schwaiger; Adnan Kastrati; Karl-Ludwig Laugwitz; Christoph Rischpler; Tareq Ibrahim Journal: Eur J Nucl Med Mol Imaging Date: 2020-05-30 Impact factor: 9.236
Authors: Henk Everaars; Stefan P Schumacher; Wijnand J Stuijfzand; Martijn van Basten Batenburg; Jennifer Huynh; Pepijn A van Diemen; Michiel J Bom; Ruben W de Winter; Peter M van de Ven; Ramon B van Loon; Albert C van Rossum; Maksymilian P Opolski; Alexander Nap; Paul Knaapen Journal: Int J Cardiovasc Imaging Date: 2021-08-02 Impact factor: 2.357